Editor Associate Editors H. Joseph Newton Francis X. Diebold, University of Pennsylvania Department of Statistics Joanne M. Garrett, University of North Carolina Texas A & M University Marcello Pagano, Harvard School of Public Health College Station, Texas 77843 James L. Powell, UC Berkeley and Princeton University 409-845-3142 J. Patrick Royston, Royal Postgraduate Medical School 409-845-3144 ...

In the adult brain, subsets of astrocytic cells residing in well-defined neurogenic niches constitutively generate neurons throughout life. Brain lesions can stimulate neurogenesis in otherwise non-neurogenic regions, but whether local astrocytic cells generate neurons in these conditions is unresolved. Here, through genetic and viral lineage tracing in mice, we demonstrate that striatal astroc...

Liposomes entrapping gadolinium-DTPA (Gd-DTPA) were synthesized from 60 mole percent egg phosphatidylcholine (EPC) and 40 mole percent cholesterol or EPC alone entrapping Gd-DTPA in diameters of 100 and 200 nm. Rats bearing Morris hepatoma in their flanks were imaged by MR pre- and post-contrast with free Gd-DTPA and liposomal Gd-DTPA for up to four hours after IV contrast. Comparison of images...

UNLABELLED Antibodies accumulate nonspecifically in infectious foci due to the locally increased vascular permeability. This study describes a method of infection imaging in which 99mTc-DTPA (diethylenetriaminepentaacetic acid) is trapped at the target by a previously administered anti-DTPA monoclonal antibody. DTIn1. METHODS Rats with Staphylococcus aureus-infected calf muscle were injected ...

UNLABELLED Receptor-targeted scintigraphy and radionuclide therapy with radiolabeled somatostatin analogs are successfully applied for somatostatin receptor-positive tumors. The synergistic effects of an apoptosis-inducing factor, for example, the Arg-Gly-Asp (RGD) motif, can increase the radiotherapeutic efficacy of these peptides. Hence, the tumoricidal effects of the hybrid peptide RGD-dieth...

Chromium is an element that possess several oxidation states and can easily pass from one to another, so its behavior in soils very complex. For this reason, determining fate the environment be difficult. In research work we tried determine which factors affect chromium fractionation natural soils, conditioning mobility. We paid special attention parent material. purpose, extraction experiments...

BACKGROUND The newly developed magnetic-resonance-imaging (MRI) hepatocyte-specific contrast agent, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has different excretion pathways from the conventional MRI contrast agent, gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). In this study, we compare the enhancement effect of the liver and renal parenchyma betwee...

BACKGROUND Pertussis occurs in older children, adolescents and adults due to waning immunity after primary vaccination. Booster vaccination for pre-school children has been recommended in Italy since 1999. In this study (NCT00871000), the immunogenicity, safety and reactogenicity of a booster dose of reduced-antigen content diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine (...

An evaluation was done of the effect of gadolinium diethylenetriaminepentaacetic acid (DTPA) on computed tomographic (CT) studies performed after magnetic resonance (MR) imaging. CT scans of two solutions of Gd-DTPA demonstrated substantial attenuation. In two patients who underwent CT after Gd-DTPA-enhanced MR imaging, the high attenuation of concentrated Gd-DTPA was seen in the urinary bladde...