objective(s): mutant forms fms-like tyrosine kinase-3 (flt3), are reported in 25% of childhood acute lymphoid leukemia (all) and 30% of acute myeloid leukemia (aml) patients. in this study, drug response, growth promoting, and protein trafficking of flt3 wild-type was compared with two active mutants (internal tandem duplication (itd)) and d835y. materials and methods:flt3 was expressed on fact...

introduction: midazolam has turned into a common drug for pediatric procedural sedation and analgesia. however, there is not much data regarding its proper dose and potential side effects in the iranian children population. therefore, the present study was done to compare 2 doses of iv midazolam in this regard. methods:  the present clinical trial was performed to compare 0.1 and 0.3 mg/kg dose...

angelica essential oil (ao), a major pharmacologically active component of angelica sinensis (oliv.) diels, possesses hemogenesis, analgesic activities and sedative effect. the application of ao in pharmaceutical systems had been limited because of its low oxidative stability. the ao-loaded gelatin-chitosan microcapsules with prevention from oxidation were developed and optimized using response...