نتایج جستجو برای: drug efflux transporters

تعداد نتایج: 620624  

Journal: :iranian journal of pharmaceutical research 0
mitra hassany biotechnology research center, mashhad university of medical sciences, mashhad, iran. mohammad hassanzadeh khayat faculty of pharmacy, mashhad university of medical sciences, mashhad, iran. pharmaceutiacal sciences research center, mashhad university of medical sciences, mashhad, iran. javaad behravan biotechnology research center, mashhad university of medical sciences, mashhad, iran. faculty of pharmacy, mashhad university of medical sciences, mashhad, iran. jamaal kasaeeian biotechnology research center, mashhad university of medical sciences, mashhad, iran.

the drug pump protein mrp2 is a membrane drug efflux transporter widely distributed in normal and tumor tissues. its role is thought to be crucial for the disposition of many drugs and their substrates in different tissues. in this study, we aimed to examine the effects of systematic inflammation induced by lipopolysaccharide (lps) on the expression and function of this transporter in rats. jug...

2016
Lea M. Hürlimann Valentina Corradi Michael Hohl Guido V. Bloemberg D. Peter Tieleman Markus A. Seeger

Nosocomial infections with Enterococcus faecalis are an emerging health problem. However, drug efflux pumps contributing to intrinsic drug resistance are poorly studied in this Gram-positive pathogen. In this study, we functionally investigated seven heterodimeric ABC transporters of E. faecalis that are annotated as drug efflux pumps. Deletion of ef0789-ef0790 on the chromosome of E. faecalis ...

2014
Patrik Lundquist Gunilla Englund Cristine Skogastierna Johan Lööf Jenny Johansson Janet Hoogstraate Lovisa Afzelius Tommy B. Andersson

Freshly isolated hepatocytes are considered the gold standard for in vitro studies of hepatic drug disposition. To ensure a reliable supply of cells, cryopreserved human hepatocytes are often used. ABC-superfamily drug efflux transporters are key elements in hepatic drug disposition. These transporters are often considered lost after isolation of hepatocytes. In the present study, the expressio...

The present study aimed at exploring the potential of the P-glycoprotein (P-gp) transporters as a barrier to the repaglinide (REG) epithelial permeability. In-vitro intestinal absorption models, the everted gut sac, and Caco-2 cell line, were used to study the possible role of P-gp in intestinal transport of REG. In the everted gut sacs, apparent permeability coefficients showed cargo concentra...

Journal: :Drugs 2009
Xian-Zhi Li Hiroshi Nikaido

Drug efflux pumps play a key role in drug resistance and also serve other functions in bacteria. There has been a growing list of multidrug and drug-specific efflux pumps characterized from bacteria of human, animal, plant and environmental origins. These pumps are mostly encoded on the chromosome, although they can also be plasmid-encoded. A previous article in this journal provided a comprehe...

Objective(s):Transporters have an important role in pharmacokinetics of drugs. Inhibition or induction of drug transporters activity can affect drug absorption, safety, and efficacy. P-glycoprotein (P-gp) is the most important membrane transporter that is responsible for active efflux of drugs. It is important to understand which drugs are substrates, inhibitors, or inducers of P-gp to minimize...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2014
Patrik Lundquist Gunilla Englund Cristine Skogastierna Johan Lööf Jenny Johansson Janet Hoogstraate Lovisa Afzelius Tommy B Andersson

Freshly isolated hepatocytes are considered the gold standard for in vitro studies of hepatic drug disposition. To ensure a reliable supply of cells, cryopreserved human hepatocytes are often used. ABC-superfamily drug efflux transporters are key elements in hepatic drug disposition. These transporters are often considered lost after isolation of hepatocytes. In the present study, the expressio...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2008
Joseph W Polli Joan E Humphreys Kelly A Harmon Stephen Castellino Michael J O'Mara Katie L Olson Lisa St John-Williams Kevin M Koch Cosette J Serabjit-Singh

Lapatinib [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine, GW572016, Tykerb] is a tyrosine kinase inhibitor approved for use in combination with capecitabine to treat advanced or metastatic breast cancers overexpressing HER2 (ErbB2). In this work we investigated the role of efflux and uptake transporters in lapatinib dispositi...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2008
Kiran Dharmala Jin Wook Yoo Chi H Lee

Drug efflux-transporters serve as a major barrier to anticancer drugs at the target site. One strategy to enhance the therapeutic efficacy of drugs against cancer is to increase their available concentrations at the target site by suppressing or modulating efflux-transporters. This manuscript deals with the development and evaluation of the particle type drug delivery system made of stearic aci...

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