A simple, rapid, reproducible, accurate and precise Reverse Phase HPLC method was developed for the quantitative simultaneous estimation of Drotaverine hydrochloride and Paracetamol in combined tablet dosage form. Drotaverine hydrochloride is an analog of papaver and is used mainly as an antispasmodic, smooth muscle relaxant. Paracetamol has analgesic and antipyretic activity. The chromatograph...

A simple high-performance liquid chromatographic method with ultraviolet detection is proposed for the estimation of diclofenac potassium and drotaverine hydrochloride in human plasma. Liquid-liquid extraction was carried out with a mixture of dichloromethane-isopropyl alcohol (80:20, v/v). Chromatographic separation of the analytes and internal standard was achieved on an analytical 250 × 4.6 ...

Objectives: To compare the duration of labour and rate of cervical dilatation with drotaverine hydrochloride and valethamate bromide in first stage of labour. : Sixty consecutive uncomplicated primigarvida with spontaneous onset of labour, at term gestation with vertex Materials and methods presentation were selected and randomized into two groups of 30 each. One group received drotaverine hydr...

Two simple, accurate and reproducible spectrophotometric methods; Q analysis and first order derivative method have been described for the simultaneous estimation of drotaverine hydrochloride and paracetamol in combined tablet dosage form. Absorption maxima of drotaverine hydrochloride and paracetamol in distilled water were found to be 303.5 nm and 243.5 nm respectively. Beer's law was obeyed ...

Purpose: Prolong labour contributes to increased perinatal and maternal morbidity. Inhibitory impulses in the form of spasm often impair the dilatation of cervix and prolong the duration of labour. This study was undertaken to compare the effect of Tramadol Hydrochloride And Drotavarine Hydrochloride on duration of labour and rate of cervical dilatation and compare it with control group. Method...

the present work describes a reverse phase hplc method for the quantitation of drotaverine hydrochloride and mefenamic acid in human plasma. organic solvent system used for liquid extraction composed of dichloromethane, and isopropyl alcohol in the ratio 80:20 (v/v). the compounds were separated on a thermo bds hypersil c8 (25.0 cm×4.6 mm, 5 µm particle size) column in isocratic mode with a mix...

OBJECTIVE To evaluate the efficacy and safety of Drotaverine hydrochroride in children with recurrent abdominal pain. DESIGN Double blind, randomized placebo-controlled trial. SETTING Pediatric Gastroenterology clinic of a teaching hospital. PARTICIPANTS 132 children (age 4-12 y) with recurrent abdominal pain (Apley Criteria) randomized to receivedrotaverine (n=66) or placebo (n=66) orall...

The present work describes a reverse phase HPLC method for the quantitation of drotaverine hydrochloride and mefenamic acid in human plasma. Organic solvent system used for liquid extraction composed of dichloromethane, and isopropyl alcohol in the ratio 80:20 (v/v). The compounds were separated on a Thermo BDS Hypersil C8 (25.0 cm×4.6 mm, 5 µm particle size) column in isocratic mode with a mix...

The present work describes a reverse phase HPLC method for the quantitation of drotaverine hydrochloride and mefenamic acid in human plasma. Organic solvent system used for liquid extraction composed of dichloromethane, and isopropyl alcohol in the ratio 80:20 (v/v). The compounds were separated on a Thermo BDS Hypersil C8 (25.0 cm×4.6 mm, 5 µm particle size) column in isocratic mode with a mix...

PURPOSE Postoperative urinary retention (POUR) increases the duration of hospitalization and frequency and risk of urinary bladder catheterization. The objective of this study was to analyze the efficacy of intramuscularly administered drotaverine hydrochloride in the prevention of POUR in orthopedic patients. METHODS Two hundred and thirty patients 17-40 years of age undergoing lower limb or...