نتایج جستجو برای: drb1
تعداد نتایج: 3059 فیلتر نتایج به سال:
We explored the association between HLA-B and HLA-DRB1 polymorphisms reviewed clinical characteristics of systemic lupus erythematosus (SLE) in Han population Yunnan, China. Methods There were 295 patients 265 healthy control subjects (HCs) enrolled study. Clinical data blood samples collected from patients. The genotypes detected SLE HCs. Results A total 74 on loci determined 288 as well 57 re...
Autoimmune neutropenia (AIN) of early childhood is caused by autoantibodies against antigens on the neutrophil membrane. Human leukocyte (HLA) have previously been associated with AIN. This study investigated HLA-DRB1 and HLA-DQB1 alleles in 160 antibody positive patients compared 1000 controls. Increased risk was observed for DRB1*10, DRB1*14, DRB1*16 DQB1*05, lower DRB1*04, DRB1*13 DQB1*03. H...
دیابت نوع یک بیماری اتوایمیون و مولتی فاکتوریال می باشد. ژن های hla- drb1 ,-dqb1 (در منطقه hla واقع اند) قویترین ارتباط را با بیماری دیابت نوع یک نشان می دهند. ما در این تحقیق الل ها، ژنوتایپ ها و هاپلوتایپ های مستعدکننده و مقاوم کننده به بیماری دیابت نوع یک از ژن های hla- drb1 ,-dqb1 و همچنین نواحی آمینواسیدی بسیار پلی مورفیک ملکول های hla- dr?1 ,-dq?1 را در 105 فرد بیمار و 100 فرد سالم بررسی ...
BACKGOUND: The prevalence of rheumatoid arthritis (RA) and its specific autoantibodies varies in different populations. This variability depends on the genetic polymorphism immune response genes among which HLA system plays a major role. AIM: We conducted preliminary study distribution HLA-DRB1 HLA-DQB1 first field level alleles sample 100 Albanian patients with RA. METHODS: In this context, we...
HLA (Human Leukocyte Antigen) gene is located on chromosome 6’s short arm, including several loci. genotyping necessary for transplantation, especially in hematopoietic stem cell transplantation. A cross-sectional study to determine the frequency of HLA-A, HLA-B, and HLA-DRB1 alleles 122 patients admitted National Children’s Hospital Hematopoietic transplantation from year between 2010 2020. Th...
Background and Objective: The outcome of hepatitis B virus (HBV) infection may be influenced by host factors like Human Leukocyte Antigen (HLA). We have investigated HLA-A and DRB1 alleles in patients with persistent hepatitis B infection compared to subjects who had spontaneously recovered from HBV infection. To complete the findings of this study we performed another survey in certain HLA ...
Đặt vấn đề: Gen HLA (kháng nguyên bạch cầu người) nằm trên nhánh ngắn nhiễm sắc thể số 6, được chia thành 3 lớp với các locus gen khác nhau. Việc xác định kiểu là rất cần thiết trong ghép, đặc biệt ghép tế bào gốc tạo máu. Đối tượng và phương pháp: Nghiên cứu cắt ngang tỷ lệ allele HLA-A, HLA-B, HLA-C HLA-DRB1 138 người cho máu tại Bệnh viện Nhi Trung ương từ năm 2010 - 2020. Kiểu bằng pháp PCR...
Abstract Background : Suicide is a complex phenomenon determined by the interaction of various risk factors. The Major Histocompatibility Complex most polymorphic gene cluster entire human genome, being linked to both regulation immune system and psychiatric diseases. aim this study was identify HLA-DQB1 DRB1 alleles genotypes susceptible influence suicidal behavior. Methods We explored associa...
BackgroundIn patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles HLA genetic variants and manifestations in IIM.MethodsWe included 1348 IIM determined the occurrence 14 myositis-specific or –associated autoantibodies. used unsupervised cluster an...
Abstract Background and Aims The human leukocyte antigens (HLA) are the most diverse polymorphic genes in genome matching them is of vital importance for maximising survival kidney transplants. Maltese archipelago consists three inhabited islands Mediterranean Sea, with a total population just over half million people. HLA polymorphisms Malta have never been described. aim this study was to inv...
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