less than 5% of prenatal thymoctes express hla-dr before week 12 of gestation. however, the number of hla-dr- positive cells increases during the late second and third trimesters of development. to determine the role of alpha-smooth muscle actin in fetal thymic hla-dr signaling in different stages of development we examined and compared the immunohistochemical expression of alpha-smooth muscle ...

journal of accounting advances (j.a.a) vol. 2, no. 2, fall & winter 2010, ser. 59/3     extended abstract   an investigation of agency theory and signaling theory in dividend policies: the role of institutional investors   dr. g. r. karami         dr. s. mehrani               h. eskandar tehran university   introduction        dividend has a special position among decision makers. dividend poli...

acute myeloblastic leukemia is the most frequent cancer in adults and the patients have a wide range of sub-classes. hla dr negative cases represent one of the major immune-phenotypic classes.  hla-dr is routinely used to distinguish acute promyelocytic leukemia (apl) from other aml subclasses based on the immunophenotype. the tgf-b signaling pathway, as a critical regulator, guides different v...

Diabetic retinopathy (DR) is a major complication of diabetes, and causes pathological changes in retina blood vessels, as the most common cause of vision loss. Extracellular-signal-regulated kinase 5 (ERK5) is the newest discovered member in the mitogen-activated protein kinases (MAPKs) family, and recent evidence demonstrates an essential role of ERK5 signaling in the angiogenesis. However, w...

23 Amylin enhances arcuate (ARC) and ventromedial (VMN) hypothalamic nuclei leptin signaling 24 and synergistically reduces food intake and body weight in selectively bred diet-induced obese 25 (DIO) rats. Since DIO I-amylin dorsomedial nucleus (DMN)-dorsomedial VMN (VMNdm) 26 binding was reduced, we postulated that this contributed to DIO VMH leptin resistance and that 27 impairing ventromedia...

Amylin enhances arcuate (ARC) and ventromedial (VMN) hypothalamic nuclei leptin signaling and synergistically reduces food intake and body weight in selectively bred diet-induced obese (DIO) rats. Since DIO (125)I-amylin dorsomedial nucleus-dorsomedial VMN binding was reduced, we postulated that this contributed to DIO ventromedial hypothalamus (VMH) leptin resistance, and that impairing VMH (A...

objective(s):intermittent hypoxia (ih), caused by obstructive sleep apnea (osa), could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. thus, the present study aimed to explore the effect of ih on the biological functions of microglia cells. materials and methods:cell proliferation of bv2 cells after exposure to ih were o...

Apoptosis or programmed cell death is a common property of multicellular organisms (Danial and Korsmeyer, 2004; Krammer, 2000). It can be triggered by a number of factors, including UVor γ-irradiation, chemotherapeutic drugs or signaling by death receptors (DR). The DR family is part of the tumor necrosis factor receptor superfamily (Bhardwaj and Aggarwal, 2003). Triggering members of the DR fa...

Diabetic Retinopathy (DR) is a complication of diabetes associated with irreversible loss of blindness. Various types of DR have been reported like mild non-proliferative retinopathy, moderate non-proliferative retinopathy, severe non-proliferative retinopathy and proliferative retinopathy. A number of signaling mechanisms like nuclear factor kappa-B (NF-κB), cyclo-oxygenase (COX), intracellula...

s: American Epilepsy Society Meeting 2011, 2012, 2013. Funding applied: DOD grants, CURE foundation grants (not funded). Successful funding of CURE foundation dream team grant on Infantile Spasms: Some preliminary data went into a successful multi-investigator CURE foundation grant on infantile spasms. Our discovery of Wnt signaling increases in epileptogenesis set the stage for the new researc...