نتایج جستجو برای: doxorubicin

تعداد نتایج: 29822  

Journal: :physiology and pharmacology 0
mahboobeh farokhpour khadijeh karbalaie mahmood etebari hamid mirmohamad sadeghi mohammad hossein nasr-esfahani dept. stem cells, cell sciences research center, royan institute, isfahan campus, acecr, isfahan, iran marzieh nematolahi

introduction: doxorubicin is frequently used for treatment of several types of cancer. doxorubicin cardiac toxicity has limited the use of this drug. corticosteroids may prevent doxorubicin induced cardiotoxicity. therefore the aim of this study was to evaluate mouse embryonic stem cells derived cardiomyocytes as a model to evaluate the effect of doxorubicin and dexamethasone. methods: mouse em...

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Journal: Physiology and Pharmacology 2008
Hamid Mirmohamad Sadeghi, Hossein Baharvand, Khadijeh Karbalaie, Mahboobeh Farokhpour, Mahmood Etebari, Marzieh Nematolahi, Mohammad Hossein Nasr-Esfahani,

Introduction: Doxorubicin is frequently used for treatment of several types of cancer. Doxorubicin cardiac toxicity has limited the use of this drug. Corticosteroids may prevent doxorubicin induced cardiotoxicity. Therefore the aim of this study was to evaluate mouse embryonic stem cells derived cardiomyocytes as a model to evaluate the effect of Doxorubicin and dexamethasone. Methods: Mouse ...

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ژورنال: علوم تغذیه و صنایع غذایی ایران 2020
Galedari, M, Khorsandi, L, Nikbakht, M, Shekarriz, H,

Background and Objectives: Doxorubicin-increased oxidative stress destroys tumors and normal cells, especially in heart tissues. The objective of the present study was to investigate effects of eight weeks of aerobic training and crocin consumption on doxorubicin induced heart tissue oxidative stress in male rats.  Materials & Methods: In this experimental study, 50 male rats were randomly div...

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Journal: :iranian journal of basic medical sciences 0
elmira barzegar molecular research lab, department of pharmacology and toxicology, tehran university of medical sciences, tehran, iran shamileh fouladdel molecular research lab, department of pharmacology and toxicology, tehran university of medical sciences, tehran, iran tahereh komeili movahhed molecular research lab, department of pharmacology and toxicology, tehran university of medical sciences, tehran, iran department of molecular medicine, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran. shekoufeh atashpour molecular research lab, department of pharmacology and toxicology, tehran university of medical sciences, tehran, iran mohammad hossein ghahremani department of pharmacology and toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran

objective(s):berberine, a naturally occurring isoquinoline alkaloid, has shown antitumor properties in some in vitro systems. but the effect of berberine on breast cancer has not yet been completely studied. in this study, we evaluated anticancer properties of berberine in comparison to doxorubicin. materials and methods: the antiproliferative effects of berberine and doxorubicin alone and in c...

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Journal: مجله دانشگاه علوم پزشکی زنجان 2023
Arezoo Rajabian, Azar Hoseini, Mohaddeseh Sadat Alavi, soroush Mohammadi, Zahra Tayarani Najjaran,

Abstract  Background and Objectives: Doxorubicin as an effective chemotherapeutic agent is frequently used in various cancers. Nowadays, the application of doxorubicin is limited due to its cardiotoxic effects. The important mechanism which is involved in the cardiac injury of doxorubicin is the generation of reactive oxygen species; therefore antioxidant compounds may reduce cardiotoxicity. ...

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ژورنال: مجله پزشکی ارومیه 2020
Meghrazi, Khadije, Mir Yaghoobipoor, Seyyed Salar, Peirouvi, Tahmine, Shalizar, Ali,

Background & Aims: Doxorubicin has been widely used to treat solid tumors and blood malignancies, but its toxicity has limited its application. The aim of the present study was to investigate the protective effects of lactoferrin against doxorubicin toxicity on the main gonad of rats. Materials & Methods: 24 Adult male Wistar rats were divided into four groups. Control group received physiolog...

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ژورنال: مجله پزشکی ارومیه 2017
دبیدی روشن, ولی الله, مظاهری, زهره, پارسایی فر, احمد,

Background & Aims: Despite confirmed effectiveness of forced exercise training in reducing doxorubicin-induced cardiotoxicity, the role of voluntary physical activity in reducing doxorubicin-induced cardiotoxicity, especially in the elderly, still has not been investigated properly. The aim of this study was to investigate the protective effect of cardiac protection caused by voluntary phy...

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Journal: :Nepalese journal of cancer 2022

Objective: To study the protective effect of Esculetin on myocardial injury induced by doxorubicin and explore mechanism in rats. Methods: Doxorubicin(2.5mg/kg) was injected intraperitoneally every other day for 6 times to establish a rat model injury. The effects different doses (10mg/kg & 20mg/kg) serum enzymes tissue were observed. Results: Doxorubicin significantly increased content int...

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Journal: :iranian journal of pharmaceutical research 0
issa amjadi iomaterial group, faculty of biomedical engineering (center of excellence), amirkabir university of technology, p. o. box: 15875-4413, tehran, iran. mohammad rabiee iomaterial group, faculty of biomedical engineering (center of excellence), amirkabir university of technology, p. o. box: 15875-4413, tehran, iran. motahare-sadat hosseini 1- biomaterial group, faculty of biomedical engineering (center of excellence), amirkabir university of technology, p. o. box: 15875-4413, tehran, iran. 2- polymer group, polymer engineering department (center of excellence), amirkabir university of technology, p. o. box: 15875-4413, tehran, iran.

attempts have been made to prepare nanoparticles based on poly(lactic-co-glycolic acid) (plga) and doxorubicin. biological evaluation and physio-chemical characterizations were performed to elucidate the effects of initial drug loading and polymer composition on nanoparticle properties and its antitumor activity. plga nanoparticles were formulated by sonication method. lactide/glycolide ratio a...

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Journal: :research in pharmaceutical sciences 0
h sadeghi-aliabadi m minaiyan a dabestan

doxorubicin is a broad spectrum antibiotic used in the treatment of cancers. its dose dependent cardiotoxicity is the most serious side effect causing withdrawal of drug from hard chemotherapeutic regimen. statins are shown to be cytotoxic in concentrations higher than the effective doses for the treatment of hypercholesterolemia (40 mg/day). co-administration of statins and chemotherapeutic ag...

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