نتایج جستجو برای: double strand break

تعداد نتایج: 297026  

Journal: :iranian journal of medical physics 0
abasalt hosseinzadeh colagar department of molecular and cell biology, faculty of basic sciences, university of mazandaran seyed mohsen mortazavi department of molecular and cell biology, faculty of basic sciences, university of mazandaran vahid arab-yarmohammadi department of molecular and cell biology, faculty of basic sciences, university of mazandaran farshad sohbatzadeh department of atomic and molecular physics, faculty of basic sciences, university of mazandaran

introduction the aim of this study was toinvestigate the sterilization potential of atmospheric pressure plasma jet (appj) and interactions of this technology with double-stranded dna using the polymerase chain reaction (pcr) and single-strand conformation polymorphism (sscp) techniques. materials and methods the plasma jet was produced through a high voltage sinusoidal power supplyusing a mixt...

A Alipoor R Fardid, S Sharifzadeh

Objective: Coronary heart disease (CHD) is one of the most common diseases. Coronary angiography (CAG) is an important apparatus used to diagnose and treat this disease. Since angiography is performed through exposure to ionizing radiation, it can cause harmful effects induced by double-stranded breaks in DNA which is potentially life-threatening damage. The aim of the present study is to inves...

Journal: :Current Biology 2009
Kevin Hiom

In bacteria, the RecF pathway plays an important role in the repair of DNA breaks and gaps. Reconstitution of this reaction in vitro has revealed similarities with double-strand break repair in eukaryotes.

Journal: :Genetics 2006
Dena M Johnson-Schlitz William R Engels

When a double-strand break has a gap between the broken ends, the missing information can be restored through synthesis from a homologous template. Here we address the question of how long such a gap can be before this process fails. We measured the frequency of homologous repair in the Drosophila germ line following the creation of gaps of specific sizes ranging from 3.8 to 210 kb. We found th...

Journal: :Journal of Biological Chemistry 1997

Hossein Tavakoli-Anbaran, Nadere Naderi

Introduction: Passage of ionizing radiation through the organs of living creatures develops clusters of damaged nucleotides inside the DNA rounds. 192Ir Gamma source is one of the most widely used sources in brachytherapy of cervical and prostate cancer. Thus, in this research, we investigated the flux of photons and its resulting secondary electrons, the single-strand break (S...

Journal: :The Journal of Cell Biology 2005
Dawit Kidane Peter L. Graumann

We show that RecN protein is recruited to a defined DNA double strand break (DSB) in Bacillus subtilis cells at an early time point during repair. Because RecO and RecF are successively recruited to DSBs, it is now clear that dynamic DSB repair centers (RCs) exist in prokaryotes. RecA protein was also recruited to RCs and formed highly dynamic filamentous structures, which we term threads, acro...

Journal: :The Journal of biological chemistry 1997
G Chu

DNA double-strand breaks (DSBs) are the most dangerous form of DNA damage and can lead to death, mutation, or malignant transformation. Mammalian cells use three major pathways to repair DSBs: homologous recombination (HR), classical nonhomologous end joining (C-NHEJ), and alternative end joining (A-NHEJ). Cells choose among the pathways by interactions of the pathways with CtIP and 53BP1. HR i...

Journal: :Current Biology 1999

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