The aim of the study was to detect changes of the QT dispersion (QTd) due to cardiotoxicity of tricyclic antidepressant dosulepin. Electrocardiographic and body surface potential mapping (BSPM) recordings were obtained using Cardiag 112.2 diagnostic system from 27 psychiatric outpatients treated with prophylactic doses of dosulepin and compared to those obtained from 37 healthy volunteers. From...

The aim of the study was to detect the changes of QT dispersion (QTd) due to cardiotoxicity of tricyclic antidepressant dosulepin. Electrocardiographic and vectorcardiographic recordings were obtained using Cardiag 112.2 diagnostic system from 28 psychiatric outpatients treated with prophylactic doses of dosulepin and compared to those obtained from 37 healthy volunteers. From these recordings ...

A sensitive, selective and precise high performance liquid chromatographic method has been developed and validated for the simultaneous determination of Dosulepin and Methylcobalamin in tablet dosage form. The method employed waters xterra C8 column (150 x 4.6 mm , 5 μm particle size) as the stationary phase while Acetonitrile, 0.1 M H3PO4 (70:30,v/v) was used as mobile phase. The Retention tim...

OBJECTIVE To assess whether use of the antidepressant venlafaxine is associated with an increased risk of sudden cardiac death or near death compared with other commonly used antidepressants. DESIGN Population based observational study. SETTING We did a nested case-control analysis within a new user cohort formed using the United Kingdom General Practice Research Database. PARTICIPANTS Ne...

dosulepin and doxepin are tricyclic antidepressants. the molecular geometries, harmonic vibrational frequencies, quantum chemical parameters and thermodynamic properties of dosulepin and doxepin were calculated by generalized gradient approximation methods developed by perdew and wang (gga-pw91) and becke-lee-yang-parr (gga-blyp) in the gas phase and solution media. the local reactivity of thes...

Dosulepin and doxepin are tricyclic antidepressants. The molecular geometries, harmonic vibrational frequencies, quantum chemical parameters and thermodynamic properties of dosulepin and doxepin were calculated by Generalized Gradient Approximation methods developed by Perdew and Wang (GGA-PW91) and Becke-Lee-Yang-Parr (GGA-BLYP) in the gas phase and solution media. The local reactivity of thes...

Background: This research was focused on the development of a quick, simple, precise, and cost-effective voltammetric method for quantifying dosulepin. Materials Methods: The antidepressant drug (dosulepin) assessed in pharmaceutical formulations using square wave (SWV) Differential pulse (DPV) techniques at glassy carbon potentiometric working electrodes (GCE). Results: Dosulepin demonstrated ...

Background Antidepressants are commonly prescribed. There clear national guidelines in relation to treatment sequencing. This study examines trends and variation antidepressant prescribing across English primary care. Aim To examine England, with a focus on: monoamine oxidase inhibitors (MAOIs); paroxetine; dosulepin trimipramine. Design & settin g Retrospective longitudinal using practice-...

In order to clarify the mechanism underlying the anti-obesity effects of sibutramine, we examined the effects of sibutramine on extracellular levels of dopamine and 5-hydroxytryptamine (5-HT) through microdialysis in the striatum in unanesthetized and freely moving rats. Sibutramine (5 mg/kg, oral administration (p.o.)) increased extracellular dopamine and 5-HT levels in rat striatum. The tricy...