rosai-dorfman disease or sinus histiocytosis with massive lymphadenopathy is a rare disorder that typically manifests as lymphadenopathy and systemic symptoms whose etiology remains poorly elucidated. the diagnosis is based on immunohistochemistry. its treatment is poorly defined but the prognosis is usually favorable. here we report a 14 year old boy who presented with massive bilateral cervic...

Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy is a rare disorder that typically manifests as lymphadenopathy and systemic symptoms whose etiology remains poorly elucidated. The diagnosis is based on immunohistochemistry. Its treatment is poorly defined but the prognosis is usually favorable. Here we report a 14 year old boy who presented with massive bilateral cervi...

any patient with bilateral lymphadenopathy especially in indian subcontinent is regarded as suffering from tuberculosis unless proved otherwise. this sometimes leads to unwarranted delay in correct diagnosis and management if there is ignorance regarding other rarer etiologies. rosai-dorfman disease (rdd) may present in the same manner and should always be kept on the back of the mind to help a...

Rosai-Dorfman disease is a rare benign histiocytic disease that infrequently presents in the spine. We report a case of Rosai-Dorfman disease isolated to the epidural thoracic spine in a 26-year-old male. To our knowledge, this is the 15th reported case of isolated spinal disease and only the fourth case of isolated thoracic epidural disease. Given its rarity as well as non-specific symptoms an...

1. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathological entity. Arch Pathol. 1969;87 (1):63-70. 2. Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol. 1990;7(1):19-73. 3. Eisen RN, Buckley PJ, Rosai J. Immunophenotypic characterization of ...

CRDD: cutaneous Rosai-Dorfman disease RDD: Rosai-Dorfman disease INTRODUCTION Rosai-Dorfman disease (RDD) is a benign nonLangerhans cell histiocytic disorder often involving the cervical lymph nodes. Extranodal disease was reported in 43% of patients with RDD in a review of the literature, with the skin reported to be the most common extranodal site. In the absence of lymph node involvement, RD...

INTRODUCTION Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman Disease, is a rare and benign source of lymphadenopathy first described in 1969, which mimics neoplastic processes. This disease commonly presents in children and young adults with supra-diaphragmatic lymphadenopathy or extranodal lesions consisting of tissue infiltrates composed of a polyclonal populatio...

Rosai-Dorfman disease is a benign histiocytic proliferative disorder of unknown etiology. The disease mainly affects lymph node tissue, although it is rarely confined to the skin. Here, we describe a 53-year-old woman with purely cutaneous Rosai-Dorfman disease. The patient presented with a large pigmented plaque on her left leg, and sparse erythematous papules on her face and arms. A complete ...

ESR: erythrocyte sedimentation rate INTRODUCTION Rosai-Dorfman disease, also called sinus histiocytosis with massive lymphadenopathy, is a rare histiocytic condition of unknown etiology first described in 1969. Primary cutaneous manifestation without systemic involvement of Rosai-Dorfman disease is even more uncommon. Here we present a case of primary cutaneous manifestation of Rosai-Dorfman di...

a 35-year-old man was admitted because of a 2-year history of nasal obstrction, a nasopharyngeal mass, malaise, and massive cervical lymphadenopathy. nasal symptoms and nasopharygeal mass were due to rhinoscleroma that was confirmed by an incisional biopsy and culture. the patient underwent cervical lymph node biopsy and culture. the patient underwent cervical lymph node biopsy that revealed th...