in this investigation wer studied the effect of dopaminergic system on the conflict behavior in rat, using vogel’s test. the related drugs were injected intraperitonealy (ip), and produced the following results:diazepam at doses of 0.5 and 1 mg/kg increased the lick –shock responses in the vogel’s thest. quinpirole (d2-agnosit), at doses of 0.1 and 10 mg/kg, increased the confict responses, whe...

OBJECTIVE To investigate the use of dopaminergic and serotonergic drugs in elderly people. METHODS We analyzed data on age, sex and dispensed drugs for individuals aged ≥65 years registered in the Swedish Prescribed Drug Register from July to September 2008 (n = 1,347,564; 81% of the total population aged ≥65 years in Sweden). Main outcome measures were dopaminergic (enhancing and/or lowering...

AMA Rybakowski J. Sixty-year history of dopaminergic mechanism antipsychotic drugs. Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii. 2023;39(1):9-17. doi:10.5114/fpn.2023.127421. APA Rybakowski, (2023). Neurologii, 39(1), 9-17. https://doi.org/10.5114/fpn.2023.127421 Chicago Janusz. 2023. "Sixty-year drugs". Neurologii 39 (1): Harvard pp.9-17. MLA drugs." v...

Drug-induced changes in the functional properties of neurons in the mesolimbic dopaminergic system are attractive candidates for the molecular underpinnings of addiction. A central question in this context has been how drugs of abuse affect synaptic plasticity on dopaminergic cells in the ventral tegmental area. We now know that the intake of addictive drugs is accompanied by a complex sequence...

BACKGROUND The dopaminergic system is involved in a wide range of cognitive functions including motor control, reward, memory, attention, problem-solving and learning. This has stimulated interest in investigating the potential of dopaminergic drugs as cognitive enhancers in aphasic patients. AIM To discuss the evidence for the use of dopaminergic agents in patients with aphasia. Levodopa (L-...

According to the dopamine hypothesis of schizophrenia, symptoms of psychosis arise, in part, from dysregulation of central dopaminergic pathways. The activity of dopaminergic neurons is in turn modulated by several neurotransmitters, including, most prominently, serotonin and glutamate. The first generation of antipsychotic drugs (ie, typical antipsychotics) are characterized by potent D2 dopam...

Antipsychotic drugs currently in use have been developed as antidopaminergic agents; that is, normalization of psychotic symptoms occurs through a reduction in dopaminergic activity, usually by blockade of postsynaptic dopamine receptors. Based on this current understanding of the mechanism of action of antipsychotic drugs, it is suggested that one physiological role of the dopaminergic system ...

Food, drugs and brain stimulation can serve as strong rewarding stimuli and are all believed to activate common brain circuits that evolved in mammals to favour fitness and survival. For decades, endogenous dopaminergic and opioid systems have been considered the most important systems in mediating brain reward processes. Recent evidence suggests that the endogenous cannabinoid (endocannabinoid...