introduction renal tubular acidosis (rta) is a non-uremic defects of urinary acidification. it is characterized by a normal anion gap hyperchloremic  metabolic acidosis; plasma potassium may be normal, low or high-depending on the type of rta. these syndromes differ from uremic acidosis which is associated with a high anion gap, decreased glomerular filtration with enhanced proton secretion by ...

Renal tubular acidosis (RTA) is a non -uraemic clinical syndrome of disordered renal acidification.1 In the classic distal RTA (Type 1), subjects have hyperchloraemic acidosis, hyponatraemia and hypokalaemia. The urinary pH remains high (pH > 6.2), even in the presence of systemic acidosis. Although the defect is permanent, the prognosis is good when the diagnosis, with correct management, is e...

OBJECTIVES We have analysed the association between different parameters of renal tubular acidosis (RTA) with clinical and laboratory parameters in patients with systemic lupus erythematosus (SLE). METHODS Review of hospital database records between 1978 and 2003 revealed six SLE patients with RTA. Correlations and comparisons were done by Spearman rank correlation coefficient and the chi(2) ...

OBJECTIVE (i) To examine the usefulness of urinary net charge (UNa + UK - UCl) in the evaluation of hyperchloremic metabolic acidosis secondary to diarrhea, distal RTA and proximal RTA and (ii) To characterize the type of distal RTA on the basis of the underlying defect. SETTING Pediatrics division of a tertiary referral center. SUBJECTS Thirty four children with hyperchloremic metabolic ac...

Type I (distal) renal tubular acidosis (RTA) is a disorder associated with the failure to excrete hydrogen ions from the distal renal tubule. It is characterized by hyperchloremic metabolic acidosis, an abnormal increase in urine pH, reduced urinary excretion of ammonium and bicarbonate ions, and mild deterioration in renal function. Hypercalciuria is common in distal RTA because of bone resorp...

Hypokalemia is a common electrolyte abnormality and if neglected, it may be fatal. This type of electrolyte abnormality is seen in distal renal tubular acidosis (RTA). Respiratory paralysis in distal RTA due to hyokalemia is a rare clinical entity described in the literature. Here we discuss one such case: a 25-year-old female presented with complaints of acute onset symmetrical weakness of bil...

Distal renal tubular acidosis (RTA) with sensorineural deafness is a rare entity, inherited in an autosomal recessive manner. It is caused by mutations in the ATP6V1B1 gene, leading to defective function of H+-ATPase pump in the distal nephron, cochlea and endolymphatic sac. We report two siblings with distal RTA and sensorineural deafness having mutation in the first coding exon of the gene, r...

Severe hypokalemia is a central feature of the classic type of distal renal tubular acidosis (RTA), both in hereditary and acquired forms. In the past decade, many of the genetic defects associated with the hereditary types of distal RTA have been identified and have been the subject of a number of reviews. These genetic advances have expanded our understanding of the molecular mechanisms that ...

Renal Tubular Acidosis (RTA) is a clinical syndrome characterised by metabolic acidosis secondary to a disorder in renal acidification. The acidification may be manifested by a defect in the renal tubular reabsorption of bicarbonate and/or urinary excretion of hydrogen ion1 -3. In terms of clinical and physiopathological aspects this disease can be classified into three groups: distal RTA or ty...

INTRODUCTION Renal tubular acidosis (RTA) is a rare disease characterized by a normal serum anion gap, sustained metabolic acidosis, low concentration of plasma bicarbonate, variable hyperchloremia and hypokalemia and conserved glomerular filtration rate. RTA is developed during the first year of life and produces failure to thrive and anorexia. Primary distal RTA (type 1) is a renal syndrome w...