a major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. if the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. although some approaches are available for enhancing the diss...

S resulting in sinkholes within dissolution mine fields in and around the city of Hutchinson, Kansas, USA (Figure 1) has been reported for more than 90 years. Salt dissolution and the resulting unpredictable upward migration of the dissolution voids can be observed both in proximity to well bores (dissolution mining, brine disposal, and oil wells; seismic shot holes, etc.) and in areas known to...

Ethylenediamine tetraacetate (EDTA)-mediated calcite dissolution occurs via a different process than water-promoted dissolution. Near-atomic-scale observations in EDTA solutions demonstrate that, after penetration through a critical pit depth barrier, step velocity increases linearly with pit depth for EDTA-promoted dissolution. The parallel processes of water-dominated dissolution at point def...

Hesperidin nanocrystals was generated by high pressure homogenization. The physicochemical properties of a spray dried hesperidin nanocrystals were investigated including to re-dispersion, crystalline state, kinetic solubility, dissolution velocity. Hesperidin nanosuspension with concentration of 10% (w/v) was dried by a Mini Spray-dryer B-190. Photon correlation spectroscopy (PCS) and laser di...

At present about 40% of the drugs being in the development pipelines are poorly soluble, even up to 60% of compounds coming directly from synthesis are poorly soluble [1]. Poor solubility is in most cases associated with poor bioavailability. According to the Noyes-Whitney law the dissolution velocity dc/dt depends on the saturation solubility cs. There are two basic approaches to overcome the ...

The nanoparticles for pharmaceutical application are around now for over 35 years, but only few are commercialized. The major hurdle in its effective utilization is lack of basic understanding in nanosuspension solidification techniques. This study evaluates the efficacy of high shear granulation in converting nanosuspension to solid oral dosage form. Nanosuspension was manufactured using a med...

USP dissolution Apparatus 4 can have a pulsing or non-pulsing flow, with most commercial apparatus employing a pulsing flow. Overall, a low velocity flow field is present, particularly in the larger 22.6-mm diameter cell. Dissolution data, computational fluid dynamics (CFD), and imaging methods are used and discussed to investigate the effects of low velocity pulsing flow on dissolution. Local ...

This paper presents a possible way to understand dissolution of OB associations (or groups). Assuming rapid escape of parental cloud gas from associations, we show that the shadow of the formation environment for associations can be partially imprinted on the velocity dispersion at their dissolution. This conclusion is not surprising as long as associations are formed in a multiphase interstell...