Dissolution behaviour of pure cefprozil monohydrate (CM) and cefuroxime axetile (CA) and their marketed tablets have been studied in aqueous as well as micellar media. Dissolution of cefprozil monohydrate is significantly assisted in presence of sodium dodecyl sulphate (SDS) and cetyltrimethylammonium bromide (CTAB). But, SDS and CTAB behave differently in accelerating the dissolution tendency ...

I discuss the possibility that the quark-gluon plasma at strong coupling admits a description in terms of a black hole in asymptotically anti-de Sitter space. Prepared for the Proceedings of Recent Developments in Gravity – NEB XIII, Thessaloniki, Greece, June 2008. Research supported in part by the US Department of Energy under grant DE-FG05-91ER40627. E-mail: [email protected]

Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA) has allowed the replacement of dissolution testing with disintegration ...

a simple and sensitive chemiluminescence-based method was established for the determination of rabeprazole.the proposed method was based on the enhancing effect of rabeprazole on ce(iv)-na2so3 -tb(iii) chemiluminescence reaction. a possible mechanism was discussed for chemiluminescence system by studying uv-vis, fluorescence and chemiluminescence spectra. the effects of various chemical paramet...

European Journal of Pharmaceutical Sciences 13 2001 123133 www.elsevier.nllocateejps. Modeling and comparison of dissolution profiles.To compare dissolution profiles between two drug products model dependent curve fitting, statistic analysis and model independent methods can be used. To compare dissolution profiles between two drug products model dependent curve fitting, statistic analysis and ...

Naproxen is a poor water soluble, non-steroidal analgesic and anti-inflammatory drug. The enhancement of oral bioavailability of poor water soluble drugs remains one of the most challenging aspects of drug development. Although salt formation, solubilization and particle size reduction have commonly been used to increase dissolution rate and thereby oral absorption and bioavailability of low wa...

Curcumin is a phytoconstituent with wide range of biological activity. It is poorly soluble in water. In the present study a new dissolution medium was developed, as there is no validated dissolution method available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37 degrees . Solubility data revealed that addition of surfactant may b...

In vivo dissolution of crystalline insulin formulations is an important step for insulin absorption in the subcutaneous therapy of diabetes, which is the most widespread. Here, data on the in vitro dissolution of three different crystalline forms of commercial porcine insulin are reported. The aim of this study was to create a model framework of in vivo dissolution of insulin crystalline formul...

Clarithromycin (CLA), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. The aim of this investigation was to prepare CLA nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. Different weight rati...