the (bacille calmette-gue´rin) bcg is widely practiced in many countries in pediatric group and is a part of routine vaccination program at birth in ir. iran for prophylaxis against tuberculosis, but its efficacy is a matter of debate in different geographic and ethnic regions. adverse reactions induced by bcg vaccination ranges from bcg adenitis, osteitis, and cold abscess at vaccination site ...

conclusions disseminated bcg infection should be considered in the differential diagnosis of infants and young children with fever, hepatosplenomegaly, lymphadenopathy, and history of bcg vaccination. the pcr method has a high positivity rate and can serve as a useful tool for the rapid and specific identification of m. bovis bcg substrain infection. results from the total of 34 children hospit...

bcg (bacille calmette–guérin) vaccine is administered worldwide to prevent severe forms of tuberculosis. it is considered to be safe; however, occasional complications are seen. the most serious complication is bcgosis. we report a case of bcgosis with granulomatous hepatitis and acid-fast bacilli in liver and spleen. we treated the patient with antituberculosis drugs without any response to tr...

Interleukin 12 receptor beta 1 (IL12Rβ1) deficiency is the most common cause of Mendelian susceptibility to mycobacterial disease (MSMD). MSMD usually predisposes affected individuals infections with weakly virulent mycobacteria such as Bacille Calmette-Guérin (BCG), environmental mycobacteria, non-typhoidal Salmonella, and certain other intracellular pathogens. presents disseminated BCG infect...

Background: Disseminated bacilli calmette-Guerin (BCG) infection after inoculation with live vaccine is considered to result from impaired immunity of the child. However, half of the cases are regarded as idiopathic because no well-defined immunodeficiency condition can account for the infection. Case report: An 8-month-old male infant was admitted with an ulcer on his left arm at the site ...

bacillus calmette guerin (bcg) developed by albert calmette and camille guerin in france between 1908 and 1921 contained a live attenuated strain of mycobacterium bovis and was administered worldwide to prevent tuberculosis. bcg vaccination is also administered at birth to all the newborns in iran. disseminated bcg infection after bcg vaccination is rare. here in, we report 2 new cases of disse...

Background: Bacillus Calmette-Guérin (BCG) vaccination is recommended for newborn infants worldwide to prevent tuberculosis. However, complications do occur inevitably in a very low rate, among which the most serious is disseminated disease. The disseminated bacillus Calmette–Guérin disease is a rare disease with high fatality, and can be seen among persons with an underlying immunodeficiency. ...

BACKGROUND Adverse reactions induced by BCG vaccination are rare, disseminated mycobacterial BCG infection in particular, which is often fatal and results from impaired immunity. The aim of this study is to determine the nature of the immunodeficiences in patients with disseminated BCG infection in northwest region of Iran. MATERIALS AND METHODS Through 2 years all infants with BCG adenitis o...