OBJECTIVE To demonstrate genetic influence on the onset of age-related macular disease (AMD), analyzing genotype distribution of haplotypes, including polymorphisms of genes with proved relationships with AMD risk (CFH, ARMS2, HTRA1) in patients with AMD and in healthy people. METHODS We took 101 consecutive patients with an AMD diagnosis following Wisconsin international classification. For ...

Oxaliplatin resistance in colorectal cancers (CRC) is a major medical problem, and predictive markers are urgently needed. Recently, miR-625-3p was reported as a promising predictive marker. Herein, we show that miR-625-3p functionally induces oxaliplatin resistance in CRC cells, and identify the signalling networks affected by miR-625-3p. We show that the p38 MAPK activator MAP2K6 is a direct ...

1. Proof. (a) It is known that all finite dimensional distributions of X(t) are multivariate normal with E(X(s)) = 0 and E(X(s)X(t)) = min{s, t}. It is easy to see that B(t) ∼ N(0, t), B(t′)−B(t) = X(s+ t′)−X(s+ t) ∼ N(0, t′− t) (t′ > t) and B(t0), B(t1) − B(t0), ..., B(tn) − B(tn−1) are independent. Hence all finite dimensional distributions of B(t) are multivariate normal with E(B(t)) = 0. Su...

no abstract

BACKGROUND Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease caused by loss-of-function mutations in ABCC6 and characterized by elastic calcification leading to dermal, ocular, and ischemic vascular disease. We tested the hypothesis that heterozygosity for R1141X, the most frequent PXE-causing mutation in Caucasians, associated with risk of ischemic vascular disease, as previous ...

............................................................................................................................................................................... 623 Introduction .......................................................................................................................................................................... 624 Case Study Sites ...............

no abstract

no abstract