Giving infecting bacteria a little freedom early on can be good for the host, according to a new study by Rotta et al. (page 657). Confining the bugs too quickly, they find, can tie up the immune cells that need to spread the word. Certain bacteria, such as Mycobacterium tuberculosis and Salmonella, are quickly surrounded by macrophages, dendritic cells, and other immune cells that seal off the...