BACKGROUND Immunotherapy with diphencyprone (diphenylcyclopropenone) is used in the treatment of alopecia areata (AA). Response rates have varied in the literature. OBJECTIVES To determine the efficacy of diphencyprone therapy for AA in the largest reported cohort of patients; to identify patient and treatment factors predictive of therapeutic success; and to develop a practical model for pre...

There are reported cases of diphencyprone used in treating cutaneous metastases of melanoma. Here, we report a patient with previous primary melanoma on his left back treated with surgical excision and lymphadenectomy, followed by radiotherapy for the recurrent tumor on the primary site. Despite radiotherapy and treatment with dabrafenib and trametinib, in-transit metastases have developed and ...

treatment with diphencyprone. Z Hautkr 1984; 59: 1080 ± 1083. 3. Weisshaar E, Neumann H-J, Gollnick H. Successful treatment of disseminated facial verrucae with contact immunotherapy. Eur J Dermatol 1998; 8: 488 ± 491. 4. Greenberg JH, Smith TL, Katz RM. Verrucae vulgares rejection. A preliminary study on contact dermatitis and cellular immune response. Arch Dermatol 1973; 107: 580 ± 582. 5. La...

Forty-eight patients (23 male, 25 female) with severe alopecia areata were sensitized and treated with topical diphencyprone. Thirty-eight per cent of the subjects had good regrowth of hair at a mean follow-up period of 30.8 months. The presence of nail changes, a personal history of atopy and a long duration of alopecia had an adverse prognostic effect.

Topical immunotherapy with diphencyprone (DPCP) for the treatment of severe alopecia areata has been used since 1983 and is felt to be the treatment of choice by many dermatologists. Although there have been no major side effects reported since its initial use, there remain some unknowns regarding its safety. Because DPCP has at least a 40% success rate for cosmetically acceptable regrowth in e...

This issue begins with Australian research showing that wearing superfine merino woollen clothing may help manage children with atopic dermatitis. Researchers from the US have reported that patients with hidradenitis suppurativa have changes in the expression of genes encoding enzymes involved in sphingolipid metabolic pathways. Research from Queensland reports on patients treated with diphenyl...

Dear Editor, Diphencyprone (DCP) is a contact sensitiser used to treat dermatological conditions resulting from an altered immunological state, such as extensive alopecia areata. Adverse effects include local eczema with blistering, regional lymphadenopathy and contact urticaria. Rare adverse effects include an erythema multiforme-like reaction, hyperpigmentation, hypopigmentation and vitiligo....