We have investigated the effectiveness of rectally administered dimenhydrinate on postoperative vomiting in children undergoing strabismus surgery, in a double-blind, randomized, placebo-controlled study. In one group, dimenhydrinate 50 mg was administered rectally 30 min before starting anaesthesia, whereas in the control group, placebo suppositories were given. Children who received dimenhydr...

Structured abstract Question: In patients undergoing surgery, does prophylactic dimenhydrinate reduce the frequency of postoperative nausea and vomiting (PONV) compared to placebo? Data sources: Studies were identified by computerized searches (MEDLINE, EMBASE, Cochrane Library) up to June 2001, citation review, and hand searches of locally available anesthesia journals. No language restriction...

A 19-year-old woman presented with status epilepticus and ventricular dysrhythmias less than one hour after ingesting 5,000 mg dimenhydrinate (Dramamine). Aggressive resuscitation including the use of physostigmine stabilized the cardiac rhythm; however, she suffered a severe neurologic deficit. Development of ischemic and infarcted bowel necessitated colonic resection. After surgery, her condi...

a bstra ct   background: nausea and vomiing are the common symptoms of early pregnancy. without treatment, vomiting can complicate the pregnancy, so it must be reduced. wide varieties of treatment have been used for nausea and vomiting in pregnancy. this study compared the effectiveness of vitamin b6 and dimenhydrinate for gestational nausea and vomiting.     materials and methods: one hundred ...

BACKGROUND Nausea and vomiting are the common symptoms of early pregnancy. Without treatment, vomiting can complicate the pregnancy, so it must be reduced. Wide varieties of treatment have been used for nausea and vomiting in pregnancy. This study compared the effectiveness of vitamin B6 and dimenhydrinate for gestational nausea and vomiting. MATERIALS AND METHODS One hundred and forty pregna...

serious toxicity other than some nausea. Continued treatment with intravenous theophylline resulted in compensation of her respiratory difficulties. In its literature, Clinical Assays mentions that 8-chlorotheophylline may interfere. Dimenhydrinate is the 8chlorotheophylline salt of the antihistaminic diphenhydrammne. In addition to the theophylline peak on chromatography, there was another pea...

BACKGROUND Diphenhydramine and its theoclate salt dimenhydrinate are traditional antiemetics still in use. However, so far the quantitative effect of dimenhydrinate in the prophylaxis of postoperative nausea and vomiting (PONV) has not been evaluated systematically. METHODS Results from randomized controlled trials investigating the efficacy of dimenhydrinate vs. a control to prevent PONV wer...

QUESTION Dimenhydrinate is an over-the-counter drug that is commonly used for the treatment of nausea and vomiting. Many of my adult patients use it, but is it safe and useful in the pediatric population? ANSWER Dimenhydrinate appears to be safe for use in the pediatric population. While little literature has been published about adverse effects of this medication, family physicians need to i...

OBJECTIVE To evaluate the efficacy and safety of oral dimenhydrinate in the treatment of acute gastroenteritis. METHODS This was a randomized, double-blind, placebo-controlled trial conducted in the emergency department of a pediatric university-affiliated center. Children 1 to 12 years old who presented to the emergency department with at least 5 episodes of vomiting in the previous 12 hours...