A Cu-catalyzed oxidative cross-coupling of phenols with methylboronic acid to form aryl methyl ethers has been developed, expanding the scope Chan-Evans-Lam alkylation. Electron-deficient phenol derivatives a broad array functional groups are methylated in high yields. Increased reaction temperature and catalyst loading enables methylation substrates incorporating pyridine dihydroquinolone moti...

silica ferric hydrogensulfate is an efficient heterogeneous catalyst for the cyclization of 2- aminochalcones to the corresponding 2,3-dihydroquinolin- 4(1h)-ones. this intramolecular aza michael reaction was carried out in high yields using chalcones bearing of electron donating and electron withdrawing groups. the catalyst is reusable without significant decreases in its activity after four t...

Alkene and alkyne hydroacylation reactions are archetypal examples of simple addition processes that display excellent atom economy. Both reactions result in the formation of a new C C bond and deliver synthetically useful carbonylcontaining products. In recent years, there has been considerable interest in converting these processes into synthetically useful transformations. Transition-metal-c...

Silica ferric hydrogensulfate is an efficient heterogeneous catalyst for the cyclization of 2- aminochalcones to the corresponding 2,3-dihydroquinolin- 4(1H)-ones. This intramolecular aza Michael reaction was carried out in high yields using chalcones bearing of electron donating and electron withdrawing groups. The catalyst is reusable without significant decreases in its activity after four t...

Silica ferric hydrogensulfate is an efficient heterogeneous catalyst for the cyclization of 2- aminochalcones to the corresponding 2,3-dihydroquinolin- 4(1H)-ones. This intramolecular aza Michael reaction was carried out in high yields using chalcones bearing of electron donating and electron withdrawing groups. The catalyst is reusable without significant decreases in its activity after four t...

A novel 3,4-dihydroisoquinol-1-one-4-carboxamide scaffold was designed as the basis for development of inhibitors poly(ADP-ribose) polymerase (PARP). Synthesis 3,4-dihydroisoquinol-1-one-4-carboxylic acids achieved using previously developed protocol based on modified Castagnoli-Cushman reaction homophthalic anhydrides and 1,3,5-triazinanes formaldimine synthetic equivalents. Employment 2,4-dim...