OBJECTIVE To determine the efficacy of single doses of albendazole, ivermectin and diethylcarbamazine, and of the combinations albendazole + ivermectin and albendazole + diethylcarbamazine against common intestinal helminthiases caused by Ascaris and Trichuris spp. METHODS In a randomized, placebo-controlled trial, infected children were randomly assigned to treatment with albendazole + place...

Glutathione-S-transferase (GST) a Phase-II drug detoxification enzyme, was detected in Setaria cervi, a bovine filarial parasite. In vitro effect of diethylcarbamazine, butylated hydroxyanisole and phenobarbitone on the GST of adult female S. cervi was assayed by the addition of these compounds in the maintenance medium. The specific activity of GST towards 1-chloro-2,4-dinitrobenzene was incre...

A simple, sensitive and reproducible method was developed and validated for the simultaneous estimation of diethylcarbamazine and levocetirizine in its tablet formulation by reverse phase high performance liquid chromatography using Waters1515 HPLC with UV detector at the λ(max) of 224 nm, using Princeton Sphere-100 C(18) (250×4.6 mm. 5 μ) column. The mobile phase used was 20mM potassium dihydr...

Diethylcarbamazine is a drug that is used for the treatment of filariasis in humans and animals; it also has effects on intestinal nematodes, but its mechanism of action remains unclear. Emodepside is a resistance-busting anthelmintic approved for treating intestinal parasitic nematodes in animals. The novel mode of action and resistance-breaking properties of emodepside has led to its use agai...

Two patients with loiasis in whom treatment with diethylcarbamazine had to be interrupted because of serious side effects underwent apheresis to extract microfilarias from the blood. After three apheresis sessions the number of microfilarias in the blood had dropped from 8980 to 3412/ml in one patient and from 2950 to 1840/ml in the other. Between 40 and 45 X 10(6) microfilarias were removed fr...

NATARAJAN, P. N., ZAMAN V. & YEOH T. S. 1973. In vitro activity of diethylcarbamazine on the infective larvae, microfilariae and adult worms of Breinlia sergenti. International Journal for Parasitology. 3: 803-807. The action of diethylcarbamazine, on the infective larvae, the microfilariae and the adult worms of Breinlia sergenti, occurring in slow loris (Nycticebus coucang) is described. The ...

a 7 year-old male presented with recurrent fever, cough and respiratory distress for over last 2 years. based on extremely high eosinophil count, high immunoglobulin e, increase in eosinophilic precursors in bone marrow, and positive antigen test for wuchereria bancrofti, a diagnosis of tropical pulmonary eosinophilia with eosinophilic leukemoid reaction was made. complete recovery was achieved...