Dicoumarols and coumarin derivatives have shown a variety of pharmaceutical activities and have been found to be potent inhibitor for the NAD(P)H-dependent flavoproteins. In this report, dicoumarol and its derivatives containing the substituted benzene ring at the methylenebis position were synthesized and evaluated for their antibacterial activity against gram-positive bacteria: Staphylococcus...

great physiological and biological activities which is further exemplified by their roles as anticoagulants (dicoumarols/ warfarins), aflatoxins and psoaralens, the important drugs in use. Apart from the above, their role as caging agents in photoactivable “caged” analogues of biomolecules, cytidine diphosphate and glutamic acid, and as probes for reactive oxygen species (ROS) spurred further i...

Density functional calculations with Becke’s three parameter hybrid method using the correlation functional of Lee, Yang and Parr (B3LYP) were carried out for 3,30-benzylidenebis(4-hydroxycoumarin) (phenyldicoumarol, PhDC), 3,30-methylenebis(4-hydroxycoumarin) (dicoumarol, DC) and the parent compound, 4-hydroxycoumarin (4-HC). Different basis sets were tested in the course of the calculations: ...

New Dicoumarols 2a-g efficiently synthesized employing p-TSA as a catalyst from the reaction of 4-hydroxycoumarin with aryl aldehydes in water. This method offers direct access to structurally diverse derivatives good yields (65-94%). Upon heating 3,3' -arylidenebis-4-hydroxycoumarins derivative acetic anhydride, epoxydicoumarins were formed. 1H, 13C{1H}-NMR, elemental analysis, and infrared sp...

Administration of heparin before the induction of nephrotoxic serum nephritis in rabbits decreases the incidence of crescent formation and glomerular sclerosis (Halpern, Milliez, Lagrue, Fray 8c Morard, 1965). Anticoagulation with a dicoumarol also decreases the amount of intraglomerular fibrin deposition (Vassalli 8c McCluskey, 1964), and it has been postulated that fibrin deposition may be an...

A homogeneous ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate doped with LiCl ([BMIm]BF4-LiCl) was found as catalyst solvents for the synthesis of dicoumarols by the condensation of 4-hydroxycoumarin and aldehyde at 80 ˚C. In this field, several types of aromatic aldehyde, containing electron-withdrawing groups as well as electron-donating groups, were rapidly changed to the correspo...

a homogeneous ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate doped with licl ([bmim]bf4-licl) was found as catalyst solvents for the synthesis of dicoumarols by the condensation of 4-hydroxycoumarin and aldehyde at 80 ˚c. in this field, several types of aromatic aldehyde, containing electron-withdrawing groups as well as electron-donating groups, were rapidly changed to the correspo...