نتایج جستجو برای: dickkopf
تعداد نتایج: 961 فیلتر نتایج به سال:
Dickkopf-1 is an inhibitor of Wnt signaling, which is crucial for osteoblast differentiation. We evaluated serum levels of Dickkopf-1 in 66 patients with thalassemia-induced osteoporosis who received therapy with zoledronic acid in a placebo-controlled, randomized trial. At baseline, thalassemia patients had increased serum levels of Dickkopf-1 that correlated with reduced bone mineral density ...
AIM To investigate the involvement of Dickkopf-1 expression in gastric cancer. METHODS Dickkopf-1 mRNA and protein expression were determined by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry in specimens of primary cancer and their adjacent noncancerous tissues in gastric cancer patients. RESULTS Dickkopf-1 mRNA and protein express...
Dickkopf-related protein 1 (DKK1) is a member of the Dickkopf gene family, which is comprised of five evolutionarily conserved members, DKK1-4 ,and a unique DKK3-related member, DKKL1 (Dickkopf-like protein 1, Soggy) (Katoh and Katoh, 2005). Dickkopf-1 is a 35kDa secreted protein involved in embryonic development; it plays a critical role in cell patterning, proliferation, and fate determinatio...
Objective. To assess serum level of Dickkopf-1 in postmenopausal females and its correlation with bone mineral density and serum biochemical markers. Methods. Bone densitometry, serum Dickkopf-1, calcium, phosphorus, and alkaline phosphatase were done in sixty postmenopausal females. Patients were divided according to T score into osteoporosis (group I), osteopenia (group II), and normal bone m...
The transforming growth factor-β (TGF-β) signalling pathway is a key mediator of fibroblast activation that drives the aberrant synthesis of extracellular matrix in fibrotic diseases. Here we demonstrate a novel link between transforming growth factor-β and the canonical Wnt pathway. TGF-β stimulates canonical Wnt signalling in a p38-dependent manner by decreasing the expression of the Wnt anta...
BACKGROUND Vitamin D deficiency remains common in all age groups and affects skeletal and non-skeletal health. Fibroblast growth factor 23 is a bone-derived hormone that regulates phosphate and 1,25-dihydroxyvitamin D homeostasis as a counter regulatory factor. 1,25-Dihydroxyvitamin D stimulates fibroblast growth factor 23 synthesis in bone, while fibroblast growth factor 23 suppresses 1,25-dih...
background: in acute myeloblastic leukemia, a large number of tumor suppressor genes are silenced through dna methylation such as cdkn2b & p73. wnt inhibitory factor 1 (wif1) and dickkopf-3 (dkk-1) are negative regulators of wnt signaling pathway. in the present study, we evaluated the methylation status of wif1 and dkk-1 genes in acute myeloblastic leukemia patients. patients and methods: bloo...
The Wnt/β-catenin signalling pathway is activated in pancreatic cancer initiation and progression. Dickkopf-related protein 3 (DKK3) is a member of the human Dickkopf family and an antagonist of Wnt ligand activity. However, the function of DKK3 in this pathway in pancreatic cancer is rarely known. We examined the expression of DKK3 in six human pancreatic cancer cell lines, 75 pancreatic cance...
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