relieving withdrawal and post-abstinence syndrome of alcoholism is one of the major strategies in the treatment of alcohol addicted patients. diazepam, chlordiazepoxide, and topiramate are the approved medications that were used for this object. to assess the role of non-pharmacologic therapy in the management of alcohol withdrawal syndrome, we analyzed effects of forced exercise by treadmill o...

BACKGROUND Behavioral effects of benzodiazepines following repeated exposure vary according to the intrinsic efficacy of the benzodiazepine studied, treatment schedule and the behavioral parameters evaluated. METHODS We applied the behavioral paradigms of spontaneous locomotor activity, elevated plus maze and grip strength to investigate the sedative, anxiolytic and myorelaxant effect of acut...

objectives: the main purpose of this experimental research was to create an animal model of ptsd based on the main features of the disorder: trauma exposure, situational reminders (sr), behavioral anxiety and remedy in response to anxiolytic medications. method: 6 inbred female sprague-dawley rats were obtained and evaluated in the elevated plus-maze test in 3 stages: 1- baseline 2- underwater ...

objective absence status epilepticus (ase) is a common form of nonconvulsive status epilepcticus. it is  characterized by loss of consciousness with spike and wave discharges in eeg simultaneously. the most effective treatment of ase is diazepam, either infusion or in divided doses; the former is more expensive since patients must be admitted in an intensive care unit. the aim of this study was...

background and objective: several studies have found that diazepam decreases serum glucose. meanwhile, glibenclamide is commonly used in diabetes treatment. the objective of this study was to survey the treatment impact of diazepam and glibenclamide on blood glucose and serum lipids in mice with type ii diabetes. materials and methods: in this study, 32 male rats were divided into four groups, ...

Benzodiazepine receptor agonists are widely prescribed therapeutic agents that alter gamma-aminobutyric acid (GABA)A activity and have anxiolytic effects. Post-operative use of benzodiazepines is a risk factor delirium. Inflammatory conditions the effects benzodiazepine. We investigated effect diazepam, typical benzodiazepine anxiolytic, on changes in emotional behavior mice hole-board test aft...

OBJECTIVE To compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of children with prolonged febrile seizures. DESIGN Prospective randomised study. SETTING Paediatric emergency department in a general hospital. SUBJECTS 47 children aged six months to five years with prolonged febrile seizure (at least 10 minutes) during a 12 mo...

A mentally retarded patient who developed polydipsia and hyponatremia following the long-term use of neuroleptics is described. Before the investigation, he was treated with a combination of five drugs: diazepam, propericiazine, carbamazepine, lithium carbonate and trihexyphenidyl. The treatment was switched to diazepam alone; to propericiazine, trihexyphenidyl and diazepam; to carbamazepine an...

Diazepam 0.05-0.25 mg/kg increased the dose of lignocaine required to cause seizures in Rhesus monkeys by 24-34%. Spontaneous ventilation was maintained adequately during lignocaine administration following diazepam treatment and no adverse cardiovascular effects occurred. Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy. However, prior t...

In a prospective study 44 children, aged 6 months to 5 years, admitted to hospital with febrile convulsions or epilepsy, were treated with diazepam in solution administered rectally during 59 generalised attacks. Rectal administration of diazepam was effective in the acute treatment of convulsions in 80% of cases. In 10% the treatment failed, whereas diazepam administered intravenously had prom...