2-Acetylcyclopentanone undergoes a smooth reaction with triphenylphosphine and dialkyl acetylenedicarboxylates to produce dialkyl 2-(1-acetyl-2-oxocyclopentyl)-3-(1,1,1-triphenyl-lambda(5)-phosphanylidene)succinates. These compounds undergo intramolecular Wittig reactions in boiling benzene to produce highly strained spirocyclobutene derivatives, which spontaneously undergo ring-opening reactio...

Three-component reaction of dialkyl acetylenedicarboxylates, isocyanides and 1,3- diimino isoindoline affords highly functionalized 2,6-dihydropyrimido[2,1-a]isoindole derivatives in good yields under catalyst free and mild reaction conditions.

The Kinetic studies were made of the reactions between triphenylphosphine, dialkyl acetylenedicarboxylates in the presence of NH-acid, such as harman. To determine the kinetic parameters of the reactions, they were monitored by UV spectrophotometery. The second order fits were automatically drawn and the values of the second order rate constant (k2) were calculated using standard equations with...

The catalyst-free multicomponent reaction of 1,2-diaminobenzene, dialkyl acetylenedicarboxylates, and ethyl bromopyruvate forms pyrrolo[1,2-a]quinoxaline derivatives in good yields. Ethylenediamine also reacts under similar conditions to produce new pyrrolo[1,2-a]pyrazine derivatives.

A one-pot and efficient approach to the synthesis of dialkyl 2-[1-[(alkoxycarbonyl)anilino]-2(1H)(isoquinolin-2-yl) (or -quinolin-1-yl or -pyridin-1-yl)]-2-butenedioates is described. This method involves a three-component reaction between isoquinoline, quinoline or pyridine, dialkyl acetylenedicarboxylates and N-phenylcarbamates under solvent-free conditions, without using any catalyst and at ...

The first investigation into two C[double bond, length as m-dash]O bonds of CO2 reacting in one reaction through dual 1,3-dipolar cycloaddition of CO2 with isocyanides and dialkyl acetylenedicarboxylates has been reported. The reaction proceeded efficiently at 80 °C at a pressure of 1 atm of CO2, affording symmetric 1,6-dioxospiro[4,4]nonane-3,8-diene derivatives in moderate yields.

A Cu-catalyzed [3+2]-type condensation reaction of oxime acetates and dialkyl acetylenedicarboxylates that provides highly substituted pyrroles under aerobic conditions is described. The newly formed pyrroles are easily employed for further transformations to prepare pyrrolo[2,1-a]isoquinoline skeletons.

Ionic liquids such as 1,3-dialkylimidazolium salts make excellent catalysts and solvents for synthesis of dialkyl 2-(dialkoxyphosphoryl)-3-(1-oxo-1-H-phthalazin-2-yl)succinates from 2H-phthalazin-1-one, dialkyl acetylenedicarboxylates, and trialkyl phosphites. Under similar conditions, triphenyl phosphite led to dialkyl 2-(diphenoxyphosphoryl)-3-(1-oxo-1-H-phthalazin-2-yl)succinates. The ionic ...

ionic liquids such as 1,3-dialkylimidazolium salts make excellent catalysts and solvents for synthesis of dialkyl 2-(dialkoxyphosphoryl)-3-(1-oxo-1-h-phthalazin-2-yl)succinates from 2h-phthalazin-1-one, dialkyl acetylenedicarboxylates, and trialkyl phosphites. under similar conditions, triphenyl phosphite led to dialkyl 2-(diphenoxyphosphoryl)-3-(1-oxo-1-h-phthalazin-2-yl)succinates. the ionic ...

stable crystalline phosphorus ylides are obtained in excellent yields from the 1:1:1 addition reactionbetween hydantoins or thiohydantoins and dialkyl acetylenedicarboxylates in the presence oftriphenylphosphine. these phosphoranes undergo smooth intramolecular wittig reaction followedby an electrocyclic ring opening to produce dialkyl (e)-2-(2,5-dihydro-5,5-diaryl-2-thioxo-1h-imidazol-4-yl)fum...