grape seed proanthocyanidin (gsp) bears a very powerful antioxidant effects. studies demonstrated that proanthocyanidins protect against free radicals mediated cardiovascular and renal disorders. the present study was designed to assess the effect of gsp on the heart of diabetic rats. forty rats were divided into four groups of 10 animals each: group i: control, group ii: control group were giv...

abstract objective: the previous studies indicated that the tlrs especially toll-like receptor 4) tlr4 (are involved in the process of diabetes. the aim of the present research was to investigate the time course expression pattern of tlr4-a main component of innate immune system- in mrna levels in the heart tissue of diabetic male wistar rats. materials and methods: in this research, adult wist...

background: to assess the effect of supplementation with vitamins a, e and c and ω-3 fatty acids on lipid peroxidation in strepto zotocin (stz) induced diabetic rats. methods: sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, dia betic with vitamin a, e as well as c supplementation and diabetic with ω-3 fatty acids supplementation. aft...

background: overexpression of lectin-like low density lipoprotein (lox-1) receptor plays an important role in hyperglycemia-induced vascular complications such as atherosclerosis. based on the beneficial effects of exercise on preventing cardiovascular complications of diabetes, we aimed to examine the protective effects of aerobic exercise on expression of lox-1 receptor and production of free...

cardiovascular disease is the common cause of mortality in diabetic subjects. recently, it is indicated that peroxisome proliferator-activated receptors (ppars) agonists have beneficial effect on cardiovascular system especially on angiogenesis. ppars have three isotypes: pparα, pparβ/δ and pparγ. in this study, we evaluated the effect of bezafibrate as pan ppar agonist on myocardial capillary ...