purpose: to report five cases of wolfram syndrome, an autosomal recessive neurodegenerative disease with ِdiabetes insipidus, diabetes mellitus, optic atrophy, and deafness (didmoad syndrome). patients and findings: all of the five patients had diabetes mellitus and optic atrophy. four patients had hearing loss. in spite of persistence of polyuria and polydipsia, diabetes insipidus had been prev...

Goals: 1. Understand diabetes insipidus and the role of arginine vasopressin production and its role at the kidney 2. Understand how to differentiate nephrogenic diabetes insipidus from central diabetes insipidus and primary polydipsia 3. Understand the etiology of nephrogenic diabetes insipidus 4. Understand the available diagnostic tools and their usefulness in characterizing the picture of n...

introduction in neonates and small infants, early diagnosis of central diabetes insipidus (cdi) and treatment with desmopressin in low doses (avoiding severe hypo- or hypernatremia) are important to prevent associated high morbidity and mortality in this particular age group. case presentetion we described pharmacokinetic and pharmacodynamic results of the use of recently launched oral desmopre...

Q1: What are the possible causes of thirst and polyuria in this woman? The two likely causes of thirst and polyuria in this patient are central diabetes insipidus secondary to previous pituitary surgery and hypercalcaemia. In our patient, a normal water deprivation test excluded central diabetes insipidus. Cranial surgery accounts for 20% cases of central diabetes insipidus in adults. After pit...

BACKGROUND Lithium can cause nephrogenic diabetes insipidus in up to 20 to 40 percent of patients currently taking the medication, and a subset of these patients will have a persistent concentrating defect long after lithium is discontinued. They are at risk for serious hypernatremia when fluid intake is restricted for any reason. METHODS MEDLINE as used to search the key words "nephrogenic d...

Q1: What are the possible causes of thirst and polyuria in this woman? The two likely causes of thirst and polyuria in this patient are central diabetes insipidus secondary to previous pituitary surgery and hypercalcaemia. In our patient, a normal water deprivation test excluded central diabetes insipidus. Cranial surgery accounts for 20% cases of central diabetes insipidus in adults. After pit...

The identification, characterization, and mutational analysis of three different genes, namely the prepro-arginine-vasopressin-neurophysin II gene (prepro-AVP-NPII), the arginine-vasopressin receptor 2 gene (AVPR2), and the vasopressin-sensitive water channel gene (aquaporin-2, AQP2), provide the basis for our understanding of three different hereditary forms of diabetes insipidus: autosomal do...

Q1: What are the possible causes of thirst and polyuria in this woman? The two likely causes of thirst and polyuria in this patient are central diabetes insipidus secondary to previous pituitary surgery and hypercalcaemia. In our patient, a normal water deprivation test excluded central diabetes insipidus. Cranial surgery accounts for 20% cases of central diabetes insipidus in adults. After pit...