neuromyelitis optica is an inflammatory demyelinating disease (idd) of the cns, which mainly affects optic nerve and spinal cord. autoantibodies against aquaporin-4 also known as nmo-igg have been implicated in the pathogenesis of nmo. we evaluated the sensitivity and specificity of nmo-igg assay for diagnosing nmo patients and differentiating them from ms patients and those with undifferentiat...

OBJECTIVE: To report a case of Devic disease, emphasizing its diagnosis, in addition to reviewing the medical literature. DESCRIPTION: Male, six-year-old patient suddenly developed weakness in lower limbs, with resolution during hospital stay. However, as the weakness disappeared, loss of vision occurred. The symptoms were reverted after the use of prednisone. COMMENTS: The diagnostic and thera...

We describe a double-transgenic mouse strain (opticospinal EAE [OSE] mouse) that spontaneously develops an EAE-like neurological syndrome closely resembling a human variant of multiple sclerosis, Devic disease (also called neuromyelitis optica). Like in Devic disease, the inflammatory, demyelinating lesions were located in the optic nerve and spinal cord, sparing brain and cerebellum, and the m...

The nasal type of extranodal natural killer (NK)/T-cell lymphoma (NKTCL) is a rare aggressive lymphoma with poor prognosis. The reported 5-year overall survival for patients with localized nasal NKTCL treated with cyclophosphamide, hydroxydaunorubicin, oncovin and prednisone (CHOP) is <50%. Dexamethasone, etoposide, ifosfamide and carboplatin (DeVIC) chemotherapy was designed as a salvage chemo...

Background and objectives. Eugène Devic (1858-1930) made medical and neurological history in 1894 when he described neuromyelitis optica (NMO). This article describes how the concept of this disease has evolved over the centuries since being described by the well-known doctor from Lyon. Methods. To describe the history of NMO, we performed a literature search in PubMed, ScienceDirect, and Googl...

background: multiple sclerosis (ms) and neuromyelitis optica (nmo) are inflammatory and demyelinating diseases of the central nervous system (cns). nk cells are supposed to play an important role in the pathophysiology of ms, but their role in the nmo remains unknown. the aim of this study was to compare the prevalence of different subpopulations of nk cells in the patients with ms and nmo and ...

OBJECTIVE Incidence of CNS acquired demyelinating syndrome (ADS), especially multiple sclerosis (MS) in children, appears to be on the rise worldwide. The objective of this study was to determine prevalence, clinical presentation, neuroimaging features, and prognosis of different types of ADS in Iranian children. MATERIALS & METHODS During the period 2002-2012, all the patients (aged 1-18 yea...