background: tamoxifen treatment induced cell death in the hippocampus formation of the prenatal and postnatal rat. the present study delineates the effect of tamoxifen on developing hippocampus in prenatal, postnatal and full term neonate rats received certain doses of the partial antagonist tamoxifen. methods: after perfusion and fixation, the brains were removed and processed for light and el...

Background: Tamoxifen treatment induced cell death in the hippocampus formation of the prenatal and postnatal rat. The present study delineates the effect of tamoxifen on developing hippocampus in prenatal, postnatal and full term neonate rats received certain doses of the partial antagonist tamoxifen. Methods: After perfusion and fixation, the brains were removed and processed for light and e...

От переводчика С разрешения авторов мы перевели первую главу их книги, и один из них (В. В.) смог найти время и просмотреть первые семь страниц перевода. Текст главы оказался весьма непривычным, а потому трудным для перевода, и мы совсем не уверены, что в нём не осталось ошибок. Надеемся, что В. В. сможет со временем просмотреть и исправить оставшуюся часть перевода, после чего можно будет данн...

GABA excites immature neurons and inhibits adult ones, but whether this contributes to seizures in the developing brain is not known. We now report that in the developing, but not the adult, hippocampus, seizures beget seizures only if GABAergic synapses are functional. In the immature hippocampus, seizures generated with functional GABAergic synapses include fast oscillations that are required...

In adult hippocampus, long-term potentiation (LTP) produces synapse enlargement while preventing the formation of new small dendritic spines. Here, we tested how LTP affects structural synaptic plasticity in hippocampal area CA1 of Long-Evans rats at postnatal day 15 (P15). P15 is an age of robust synaptogenesis when less than 35% of dendritic spines have formed. We hypothesized that LTP might ...