UNLABELLED : Diffusion maps are a spectral method for non-linear dimension reduction and have recently been adapted for the visualization of single-cell expression data. Here we present destiny, an efficient R implementation of the diffusion map algorithm. Our package includes a single-cell specific noise model allowing for missing and censored values. In contrast to previous implementations, w...

Speaking about the destiny of Man and his future is principally mixed with an argument about the destiny and the future of culture. Human destiny is determined by the culture through which he reaches perfection within his “human” identity. Now, in our times, the issue of whether culture could secure mankind from the dangers of the exploding political situation of the world is considered very im...

To enable the design of large capacity memory structures, novel memory technologies such as non-volatile memory (NVM) and novel fabrication approaches, e.g., 3D stacking and multi-level cell (MLC) design have been explored. The existing modeling tools, however, cover only a few memory technologies, technology nodes and fabrication approaches. We present DESTINY, a tool for modeling 2D/3D memori...

This paper outlines how our highly efficient, power-aware supercomputer called Green Destiny and our open-source parallelization of BLAST called mpiBLAST combine to create a bit of “bioinfomagic.” Green Destiny, featured in The New York Times and winner of a 2003 R&D 100 Award, revolutionized high-performance computing by re-defining performance to focus on issues of efficiency, reliability, an...

Differentiation to Ab secreting and isotype-switched effector cells is tightly linked to cell division and therefore the degree of proliferation strongly influences the nature of the immune response. The maximum number of divisions reached, termed the population division destiny, is stochastically distributed in the population and is an important parameter in the quantitative outcome of lymphoc...

The remote, snow-swept expanses of northern Sweden are an unlikely place to begin a story about cutting-edge genetic science. The kingdom's northernmost county, Norrbotten, is nearly free of human life; an average of just six people live in each square mile. And yet this tiny population can reveal a lot about how genes work in our everyday lives. Norrbotten is so isolated that in the 19th centu...

SUMMARY The recognition that the cosmological constant may be non-zero forces us to re-evaluate standard notions about the connection between geometry and the fate of our Universe. An open Universe can recollapse, and a closed Universe can expand forever. As a corollary, we point out that there is no set of cosmological observations we can perform that will unambiguously allow us to determine w...

a r t i c l e i n f o The current research investigates the role of implicit theories of relationships in modulating aggressive responses to ostracism. Three studies tested whether destiny beliefs (that potential relationships are either fundamentally compatible or not) predispose people to behave aggressively in the wake of ostracism. In Study 1, individual differences in destiny beliefs moder...