IT HAS BEEN demonstrated in different laboratories that chronic treatment with desoxycorticosterone acetate (DCA) induces in rats a particular type of hypertensive disease.' Observations by Friedman and Friedman, Friedman, Friedman and Nakashima, Prado and Herbert-Carrington, Magaldi and Prado showed that following abrupt interruption of the desoxycorticosterone treatment, from 30 to 40 per cen...

In the course of investigations in these laboratories on the effect of steroid hormones on various enzymatic systems, it was noted that desoxycorticosterone exerted a greater inhibitory effect than other steroids, and that the n-amino acid oxidase system was particularly strongly affected. This paper deals with experiments elucidating in part the characteristics of the n-amino acid oxidasc-deso...

The effect of specific electrolyte changes and of desoxycorticosterone on the responsiveness of vascular smooth muscle to epinephrine was studied using rabbit aortic strips. Low sodium increases, while high sodium decreases the epinephrine response. Conversely, low potassium decreases, while high potassium increases the epinephrine response. Desoxycorticosterone potentiates the epinephrine resp...

1. Desoxycorticosterone acetate (DCA) and NaCl, in the dosage employed in normal rats, caused renal and cardiac hypertrophy, characteristic changes in the renal tubular epithelium, atrophic changes in the subcapsular zone of the adrenal cortex, and serum electrolyte changes characterized by a rise in sodium and fall in potassium. 2. In rats rendered nephritic with a rabbit anti-rat-kidney serum...

background crocus sativus l. (saffron), which belongs to the iridaceae family, is widely cultivated in iran. cardiovascular effects of saffron has been established in some studies but the effects of chronic administration of saffron (c. sativus) stigma aqueous extract on blood pressure has not been investigated. objectives in this study the effects of saffron (c. sativus) stigma aqueous extract...

Rats on a stock diet with added cholesterol, cholic acid, and thiouracil developed increased concentrations of cholesterol, total lipide, and beta lipoprotein in the serum, and an increased content of cholesterol in the liver and carcass, despite the fact that the diet produced a cessation of endogenous cholesterol synthesis. Rats with high serum lipide concentrations developed intimal lesions ...