in this paper, we study the multi-depot vehiclerouting problem with inter-depot routes, in which the vehicles can replenish atintermediate depots. vehicles leave the origin depot with load on-board andserve customers until out of load. they may visit an intermediate depot toreplenish and finally return to the origin depot, completing their route. weinitiate a mathematical mixed integer programm...

OBJECTIVES To compare the pharmacodynamics and tolerability of the new goserelin acetate 10.8-mg depot with the 3.6-mg depot in patients with advanced prostate cancer during the first 3 months of therapy. METHODS One hundred sixty patients were randomized in two comparative studies to receive either the 10.8-mg goserelin acetate depot every 12 weeks or the 3.6-mg goserelin acetate depot every...

Long-acting depot antipsychotics were developed specifically to promote treatment adherence (compliance) and they are a valuable option for patients requiring maintenance medication for schizophrenia. Depot use has fallen in recent years, perhaps owing to the introduction of oral atypical antipsychotics. Psychiatrist and patient acceptance of depot medication is variable. The depot formulation ...

long protocol of gonadotropin-releasing hormone-analougue (gnrh-a) can result in the formation of ovarian cyst by the transient initial stimulatory effect which increases the levels of both follicle-stimulating hormone (fsh) and luteinizing hormone (lh). these cysts require surgical drainage or result in poor ovarian response. ovarian cyst formation can be prevented by taking oral contraceptive...

this paper considers the multi-depot vehicle routing problem with time window in which each vehicle starts from a depot and there is no need to return to its primary depot after serving customers. the mathematical model which is developed by new approach aims to minimizing the transportation cost including the travelled distance, the latest and the earliest arrival time penalties. furthermore, ...

Long protocol of Gonadotropin-Releasing Hormone-analougue (GnRH-a) can result in the formation of ovarian cyst by the transient initial stimulatory effect which increases the levels of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These cysts require surgical drainage or result in poor ovarian response. Ovarian cyst formation can be prevented by taking oral contraceptive...

BACKGROUND Risperidone long-acting injectable (RLAI), the first second-generation depot antipsychotic, has extensively been studied before introduction. Thereafter, questions about the type of patients actually treated with RLAI in daily practice remain to be answered for making valid antipsychotic treatment comparisons involving RLAI in observational studies. OBJECTIVE We aimed to determine ...

Improving outcomes in schizophrenia generally requires an improvement in medication adherence. One of the most effective interventions to improve adherence is the use of depot formulations of antipsychotic medications. A new depot aripiprazole formulation for the treatment of schizophrenia will be available soon. A review of all publically available information on depot aripiprazole as of Novem...

The aims of this retrospective study were to evaluate the efficacy of different steroid formulations (depot vs oral) and if the continuous administration of steroids throughout and beyond a CHOP protocol might improve the survival time and rate of cats with mediastinal lymphoma. The medical records of client-owned cats diagnosed with mediastinal lymphoma were reviewed at two veterinary referral...