introduction:yasthenia gravis is an autoimmune disorder resulting from a decreased number of active acetylcholine receptors at the neuromuscular junction. thymectomy is one of its current treatments. due to sensitivity of myasthenic patients to non-depolarizing muscle relaxants and also the interaction of this medication with anti-cholinestrase drugs, determining the dosage of non-depolarizing ...

Introduction:yasthenia gravis is an autoimmune disorder resulting from a decreased number of active acetylcholine receptors at the neuromuscular junction. Thymectomy is one of its current treatments. Due to sensitivity of myasthenic patients to non-depolarizing muscle relaxants and also the interaction of this medication with anti-cholinestrase drugs, determining the dosage of non-depolarizing ...

background: increase in intraocular pressure (iop) following tracheal intubation during general anesthesia can be troublesome. we compared the influence of two muscle relaxants, cisatracurium and atracurium, on iop in patients undergoing general anesthesia. methods: this randomized, double-blind, comparative trial was conducted on 90 candidates for elective non-ophthalmic surgery under general ...

Myasthenia Gravis is an autoimmune neuromuscular disorder of skeletal muscles due to the presence of acetylcholine receptor antibodies. Myasthenic patients are resistant to depolarizing relaxants such as succinylcholine but are very sensitive to non-depolarizing muscle relaxants1. That’s why, narcotic-based technique for induction and maintenance of anesthesia without muscle relaxants has been ...

Friedreich's Ataxia (FA) is a rare autosomal recessive disease. FA is clinically characterized by progressive ataxia, especially loss of reflex and power in the lower extremities, spasticity and loss of proprioceptive sensory. There is an increased sensitivity to non-depolarizing muscle relaxants in neurodegenerative diseases. Care must be taken of anesthesia management for the use of volatile ...

In summary, it appears from this and other studies that trimetaphan has the potential for producing neuromuscular blockade when used in large doses or when combined with other muscle relaxants. The mode of action appears to be principally that of non-depolarizing neuromuscular blockade. Sodium nitroprusside, on the other hand, even in doses beyond these accepted clinically, does not affect neur...

This paper will review the basics of neurostimulation in the perioperative period. Following a brief overview of neuromuscular physiology, the mechanism of action of depolarizing and non-depolarizing relaxants will be discussed. The principles of neurostimulation will then be applied clinically when different patterns of stimulation (single twitch, train-of-four, post-tetanic twitch count, doub...

The purpose of this paper is to investigate a phenomenon denied by Collins1 in 1976, but supported in later studies by Wehner 2 in 1979 and Lewis8 in 1982. The phenomenon is potentiation of the muscle relaxing action of succinylcholine by the neuroleptanesthesia agent Innovar,® as measured with a peripheral nerve stimulator. The two types of muscle relaxants used are non-depolarizing and depola...