Depo-provera, a long-acting progestational formulation, is widely used to facilitate infection of sexually transmitted diseases in animal models. We have previously reported that hormone treatments change susceptibility and immune responses to genital tract infections. In this study we compared the changes in susceptibility of mice to genital herpes simplex virus type 2 (HSV-2) after Depo-prove...

PURPOSE We compared the immediate administration of DMPA (Depo Now) to the immediate use of short-term hormonal methods that served as a "bridge method" until later DMPA initiation. We examined whether Depo Now, as compared to initiating with a bridge method (pills, transdermal patch, or vaginal ring), resulted in greater DMPA continuation at six months. METHODS Young women aged 14 to 26 year...

To the Editor:—I enjoyed the article by Dr. Stephen Abram. I would like to point out that an additional dimension to the discussion of effectiveness of epidural steroids can be found by applying the “numbers needed to treat” approach, as outlined in the excellent resource regarding the topic of pain relief using an evidence-based medicine approach published recently by McQuay and Moore. An addi...

(1) Dear Alice, I heard that while it's generally not advised to take antibiotics while on the birth control pill, it's still okay to take tetracycline. Is this true? (2) Dear Alice, I have heard many many times that antibiotics interfere with the effectiveness of oral contraceptives, but what about the depo-provera shot? Is there any research showing decreased effectiveness of Depo-Provera whe...

(1) Dear Alice, I heard that while it's generally not advised to take antibiotics while on the birth control pill, it's still okay to take tetracycline. Is this true? (2) Dear Alice, I have heard many many times that antibiotics interfere with the effectiveness of oral contraceptives, but what about the depo-provera shot? Is there any research showing decreased effectiveness of Depo-Provera whe...

Women with Lynch syndrome have a 40% to 60% lifetime risk for developing endometrial cancer, a cancer associated with estrogen imbalance. The molecular basis for endometrial-specific tumorigenesis is unclear. Progestins inhibit estrogen-driven proliferation, and epidemiologic studies have shown that progestin-containing oral contraceptives (OCP) reduce the risk of endometrial cancer by 50% in w...

(1) Dear Alice, I heard that while it's generally not advised to take antibiotics while on the birth control pill, it's still okay to take tetracycline. Is this true? (2) Dear Alice, I have heard many many times that antibiotics interfere with the effectiveness of oral contraceptives, but what about the depo-provera shot? Is there any research showing decreased effectiveness of Depo-Provera whe...

Depo-Provera® is depot medroxyprogesterone acetate (DMPA) aqueous suspension 150 mg in 1 ml formulated for deep IM injection. [2] This is most commonly used. Sayana Press® is DMPA 104 mg in 0.65 ml formulated for SC injection first licensed in the UK in 2011. [3] It is bio-equivalent to Depo-Provera®. It may be preferable to Depo-Provera® in women on anticoagulants or with a bleeding disorder. ...

To cite: Cameron S. Journal of Family Planning and Reproductive Health Care 2013;39:75–77. INTRODUCTION Since 2004, a micronised formulation of depo-medroxyprogesterone acetate (DMPA) that is delivered as a subcutaneous injection has been available. It is currently in clinical use in the USA and in nine countries throughout Europe. As of March 2013 this product is being marketed in the UK as Sa...