this study investigates the effectiveness of the antinociceptive effects of diclofenac, an nsaid, on the nociceptive behavior of morphine-treated rats on formalin test.rats were treated with morphine-containing drinking water for twenty one days, which induced morphine dependence. the antinociceptive effects of 8, 16, and 32 mg/kg doses of diclofenac were then evaluated and compared with distil...

adenosine has many of the characteristics of a regulator of cerebral blood flow and adenosine receptors change in morphine dependency. in this study the changes in adenosine receptors' responsiveness of pial vessels in the hind limb area of the sensory cortex were evaluated in morphine dependent rats (mdr) using the laser doppler flowmetry technique. adult male sprague dawley rats (250-350...

this research was designed to study sexual differences in place conditioning induced by morphine in offspring born of female wistar rats mated with drug-naïve males. mothers were exposed to morphine during the 14th-16th days of gestational. control dams were simply saline-injected. female and male virgin offspring born of morphine-treated or saline-treated mothers were separately housed until b...

introduction: dill (anethum graveolens), a herb from from umbelliferae, is used traditionally to treat convulsion and increasing milk production. its antimicrobial, antihyperlipidaemic, anti-hypercholesteroaemic effects and gastric acid secretion reducing effect have been reported. the spasmolytic effect of dill fruit on rat uterus has also been shown recently. the aim of present study was to i...

Introduction: There are many similarities between memory impairment in patients suffering from Alzheimer and animals treated by Cannabinoids. The agonists of Cannabinoid receptors affect on a variety of memories and leanings. The present study aims to investigate the role of α-1-adrenergic receptors in central region of amygdala in state-dependent learning induced by WIN55,212-2 (cannabin...

Introduction: Similarities in the memory impairment between Alzheimer patients and scopolamine treated animals have been reported. In the present study, the possible role of α-adrenergic receptors of the dorsal hippocampus on scopolamine state-dependent memory in adult male Wistar rats was evaluated. Methods: The animals were bilaterally implanted with chronic cannulae in the CA1 regions o...

Evaluation of mRNA Expression Calcitonin Gene-Dependent Peptide (CGRP) and Rat (rCT) in the Periaqueductal Gray Area (PAG) Diabetic Rats Formalin Test

background: pioglitazone from thiazolidinediones generation, represent a new antidiabetic drugs that have been introduced in the world recently. thiazolidinediones can improve insulin resistance by activating the nuclear peroxoxisome proliferator activated receptor-γ (ppar-γ) and increasing insulin sensitivity in their receptors. insulin and its receptors are found in specific areas of cns with...