endodontic intervention in necrotic immature permanent teeth is usually a clinical challenge. with appropriate case selection, regenerative treatment can be effective, providing a desirable outcome. however, there is still no consensus on the optimal disinfection protocol or the method to achieve predictable clinical outcome. this article presents two cases of regenerative treatment in necrotic...

abstract- the adverse effects of periodontal disease on dental pulp has been debated for many years. this case- control study was performed to assess the possible effects of advanced periodontal disease on the structure of dental pulp. fifty-two permanent teeth extracted because of advanced periodontitis with  5mm attachment loss and grade iii mobility were compared to fifty-two control teeth,...

Inflammatory response in the dental pulp can alter the collagen matrix formation by dental pulp stem cells and lead to a delay or poor healing of the pulp. This inflammatory response is mediated by cytokines, including interleukin-1β and tumor necrosis factor-α. In this study, it is hypothesized that suppressing the actions of these inflammatory cytokines by knocking down the activity of transc...

Biocompatibility of dentin bonding agents (DBA) and composite resin may affect the treatment outcome (e.g., healthy pulp, pulpal inflammation, pulp necrosis) after operative restoration. Bisphenol-glycidyl methacrylate (BisGMA) is one of the major monomers present in DBA and resin. Prior studies focused on salivary esterase for metabolism and degradation of resin monomers clinically. This study...

• If the pulp chamber of a tooth is penetrated, either by dental caries, or by a dental drill, inflammation and eventual death of the pulp tissue usually follows. While a long interval may elapse before degeneration is complete, necrosis is an almost inevitable consequence of pulpal penetration. A current explanation in the dental literature for this phenomenon is as follows. The application of...

The results from this study showed a variety of pulpal responses to various calcium hydroxide materials when placed directly on the dental pulp. Two of the materials proved to be more successful at stimulating reparative dentin bridging and healing of the underlying pulp tissue. The remainder of the pulp capping agents were ineffective at healing the pulp and forming a reparative dentin bridge....

tion, necrosis, and dystrophy are legion, ranging from bacterial invasion to hereditary dwarfism. Without question, bacterial invasion from a carious lesion is the most frequent initial cause of pulp inflammation. Paradoxically, an alarming amount of pulp involvement is induced by the very dental treatment designed to repair the carious lesion. An increase in automobile and cycle accidents, as ...

BACKGROUND This study explores the pattern of complications occurrence resulting from traumatic dental injuries, the relation of this pattern to the number of years from the time of the injury to its first diagnosis, and other contributing characteristics such as root development and trauma characteristic. MATERIAL AND METHODS Patients' data treated following dental trauma from 2002 to 2014 w...

Dental preparation sometimes causes transient congestion, edema, and necrosis of the pulp. We hypothesized that nitric oxide (NO) is involved in the pathophysiological changes in pulp after preparation. The mRNA and protein expression of the inducible isoform of NO synthase (iNOS) was examined in murine pulp after dental preparation. The effects of NO on the proliferation, mineralization, and a...