introduction: ca(oh) 2 -containing/forming materials are conventionally used for indirect pulp-capping and are theoretically able to release ca 2+ and oh - ions for hydrolytic dissociation. however, no evidence exists for ion diffusion through the remaining coronal dentin. the aim of this study was to design an innovative experimental set-up to test the ability of ca(oh) 2 -containing and ca(oh...

Restorative and endodontic procedures have been recently developed in an attempt to preserve the vitality of dental pulp after exposure to external stimuli, such as caries infection or traumatic injury. When damage to dental pulp is reversible, pulp wound healing can proceed, whereas irreversible damage induces pathological changes in dental pulp, eventually requiring its removal. Nonvital teet...

Lipopolysaccharide exerts many effects on many cell lines, including cytokine secretion, and cell apoptosis and necrosis. We investigated the in vitro effects of lipopolysaccharide on apoptosis of cultured human dental pulp cells and the expression of Bcl-2 and Bax. Dental pulp cells showed morphologies typical of apoptosis after exposure to lipopolysaccharide. Flow cytometry showed that the ra...

One of the causes of dental pulpitis is lipopolysaccharide- (LPS-) induced inflammatory response. Following pulp tissue inflammation, odontoblasts, dental pulp cells (DPCs), and dental pulp stem cells (DPSCs) will activate and repair damaged tissue to maintain homeostasis. However, when LPS infection is too serious, dental repair is impossible and disease may progress to irreversible pulpitis. ...

BACKGROUND AND OBJECTIVE Dental pulp repair is a common process triggered by microbial and mechanical challenges. Matricellular modulators, such as periostin, are key for extracellular matrix stability and tissue healing. In the scope of the dental pulp, periostin expression has been reported during development and active dentinogenesis. However, the specific dental pulp cell population capable...

introduction : to evaluate the clinical and radiographic outcomes of pulpotomy treatment with mineral trioxide aggregate (mta) in symptomatic mature permanent teeth with carious exposure. materials and methods: ten patients aged 27-54 years presented with 11 symptomatic permanent teeth ( n =11). each offending carious tooth was clinically and radiographically determined. we removed caries as co...

OBJECTIVES Polymerized dental resin materials release residual monomers that may interact with pulp tissues. We hypothesized that dental adhesives might cause cytotoxicity in pulp cells via the generation of reactive oxygen species (ROS), which may also contribute to genotoxic effects in vitro. METHODS For cytotoxicity testing, transformed human pulp-derived cells were exposed to extracts of ...

Capík I . , V. Ledeck ̆, A. ·evãík: Effects of Flumetazone on Exposed Dental Pulp of Dogs. Acta Vet. Brno 2003, 72: 279-283. Dental pulp metabolism plays very important role throughout the tooth life. Its role is essential particularly in the first two-three years. This is the time of the highest dentin deposition which provides sufficient firmness to withstand common everyday trauma. This study...

Biocompatibility of dentin bonding agents (DBA) and composite resin may affect the treatment outcome (e.g., healthy pulp, pulpal inflammation, pulp necrosis) after operative restoration. Bisphenol-glycidyl methacrylate (BisGMA) is one of the major monomers present in DBA and resin. Prior studies focused on salivary esterase for metabolism and degradation of resin monomers clinically. This study...

The dental pulp is characterized as a connective tissue and as such it is not considered an external tissue, yet its exposure to external stimuli is constant. This is due to a number of factors including the permeability of attrited or disrupted enamel as well as that of physiologic dentin and cementum. The pulp is extraordinarily sensitive to its external environment. Once thought to be a vest...