ultrastructural changes in immature articular carilage were studied after treatment of 5-weeks-old rats with ofloxacin, a fluoroquinolone, and in magnesium deficiency.we concluded that quinolone-induced arthropathy is probably due to chelation of functionally available magnesium in joint cartilage as magnesium deficiency in joint cartilage could impair chondrocyte-matrix- interaction which is m...

background: faba bean toxicity (favism) is a common condition observed in our region.   objective : to develop a short and simple technique involving the use of riboflavin-deficient rats to test in vivo faba bean toxicity.   methods/results: sprague dawley rats were maintained on a riboflavin-deficient diet and their vitamin b 2 status was monitored by the assay of erythrocyte glutathione reduc...

Background: Faba bean toxicity (favism) is a common condition observed in our region. Objective: To develop a short and simple technique involving the use of riboflavin-deficient rats to test in vivo faba bean toxicity. Methods/Results: Sprague Dawley rats were maintained on a riboflavin-deficient diet and their vitamin B2 status was monitored by the assay of erythrocyte glutathione reductase (...

the purpose of this study was to evaluate the effect of two regimes during rats' gestation and lactation on learning, memory and motor function of their offspring. for this purpose, female rats (albino-wistar) were obtained from pasteur institute, iran. after mating, 12 pregnant rats were divided into three groups and they had their special regimes during their last week of pregnancy as we...

We investigated the effect of dietary magnesium (Mg) level on protein utilization in rats. Male Wistar rats were fed a control diet (control group) and a Mg-deficient diet (Mg-deficient group) for 28 days. After 28 days, the diet of half of the Mg-deficient group (recovery group) was changed from the Mg-deficient diet to the control diet for either 7 or 14 days. After 28 days, final body weight...

the purpose of this study was to determine the effects of feeding iron-deficient diet during pregnancy and lactation on maternal rats. a total number of 64 rats were divided into 4 groups (pregnant), (non pregnant), (lactating) and (non lactating) with 16 animals in each group. parameters used to evaluate the effects of dietary iron deficiency on the maternal animals were: iron contents of live...

This study was aimed to establish TSH dependent, transplantable thyroid tumor (TT) in B6CsF1 (BCF1) mice. In addition, transplanted TT was examined for its growth in mice given 17/3estradiol CE2), retinoic acid (RA), tamoxifen (TAM), Ts and T4. Both sexes of BCF1 mice were observed for 12 months under IDD and distilled water CDW), starting at 4 weeks of age. Groups of mice received an i.p. inje...

The effects of some methyl-containing compounds added to a choline-deficient diet on the metallothionein mRNA level in the rat liver were studied. The addition of choline or carnitine to the choline-deficient diet did not induce a gain in body weight, while the addition of either betaine or methionine to the choline-deficient diet, or of methionine to the choline-deficient diet with choline sig...

Preclinical and clinical data indicate the involvement of zinc in the pathophysiology and therapy of depression. A relationship between zinc-deficiency and depression symptoms was recently proposed. The present study investigated alterations in spontaneous locomotor activity and zinc concentrations in the serum, hippocampus and frontal cortex; these alterations were induced by subjecting rats t...