background: for radiotherapy of total skin including sub-cutaneous tissue up to a depth of 3 cm on the entire left leg of an adult (angiosarcoma skin), a complex treatment with multiple stationary electron fields was planned at our clinic. the details of dosimetry, clinical dose measurements are presented. materials and methods: the treatment planned with 6 overlapping 9 mev electron fields in ...

Radiotherapy (RT) is a common cancer treatment but often results in an unintended injury to overlying skin and contributes impaired wound healing. Skin fibroblasts (FBs) play critical roles repair. We investigated the long-term effects of RT on FB functions understand better pathological mechanisms adverse reactions RT. collected tissue biopsies from non-irradiated (RT-) irradiated (RT+) breast...

Trypanosome parasites are hiding in human skin, a discovery that may undermine efforts to eliminate sleeping sickness by 2020.

From the Department of Medicine, University of Wisconsin–Madison School of Medicine, Madison (N.S.); the Early Intervention Program Clinic, Milwaukee Health Services, Milwaukee (C.L.A.); and the Department of Internal Medicine, University of Michigan Medical School (D.R.K., S.S.), and the Department of Veterans Affairs Health Services Research and Development Center of Excellence (S.S.) — both ...

Background Russian thistle (RT) was identified as a potentially clinically significant allergen in phase three of the NHANES survey with over 15% of tested individuals having positive skin tests. Previously estimated prevalence rates of RT skin positivity in Kingston and surrounding catchment area were ~10%. RT was subsequently added to a standard allergen skin testing panel at Queen’s Universi...

BACKGROUND Guarding pain after rat plantar incision is similar to pain at rest in postoperative patients. Spontaneous activity (SA) in nociceptive pathways quite likely transmits such ongoing pain. This study examined the extent of tissue injury by incision on pain behaviors and nociceptor SA. METHODS Rat pain behaviors were measured after a sham procedure, skin incision, or skin plus deep ti...

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, and their use in combination with radiation therapy (RT) has become increasingly utilized to optimize positive outcomes. The cutaneous adverse reactions from RT as well ICIs are both documented; however, these toxicities can be exacerbated. may work synergistically create an enhanced immune response against the tumor cells....