this study investigated the effects of two types of written feedback – direct corrective feedback (dcf) and metalinguistic explanation (me) - on iranian efl learners’ implicit and explicit knowledge of english definite and indefinite articles. assigned to three groups of dcf, me, and control groups, the participants took four tests in three testing phases: pretest, posttest, and delayed posttes...

Diclofenac (DCF) is a nonsteroidal anti-inflammatory drug commonly prescribed to reduce pain in acute and chronic inflammatory diseases. One of the main DCF metabolites is a reactive diclofenac acyl glucuronide (DCF-AG) that covalently binds to biologic targets and may contribute to adverse drug reactions arising from DCF use. Cellular efflux of DCF-AG is partially mediated by multidrug resista...

We have previously reported that mice lacking the efflux transporter Mrp3 had significant intestinal injury after toxic diclofenac (DCF) challenge, and proposed that diclofenac acyl glucuronide (DCF-AG), as a substrate of Mrp3, played a part in mediating injury. Since both humans and mice express the uptake transporter OATP2B1 in the intestines, OATP2B1 was characterized for DCF-AG uptake. In v...

Diclofenac (DCF) is a nonsteroidal anti-inflammatory drug commonly prescribed to reduce pain in acute and chronic inflammatory diseases. One of the main DCF metabolites is a reactive diclofenac acyl glucuronide (DCF-AG) that covalently binds to biologic targets and may contribute to adverse drug reactions arising from DCF use. Cellular efflux of DCF-AG is partially mediated by multidrug resista...

Docetaxel and cisplatin plus fluorouracil (DCF) is one standard regimen in the treatment of advanced gastric cancer (AGC). Due to substantial toxicity of DCF, modified DCF regimens have been developed to improve efficacy and safety. This study aimed to compare the clinical efficacy and safety between the standard DCF regimen and three common modified DCF regimens. A total of 97 consecutive AGC ...

Since distributed coordination function (DCF) is the basis protocol for IEEE 802.11 standard wireless local area networks, many modifications have been proposed in the literature to improve its throughput performance particularly under congested environments. These improvements are achieved by modifying the contention window reset mechanism in which a DCF station immediately reduces the window ...

Although the EDCA access mechanism of the 802.11e standard supports legacy DCF stations, the presence of DCF stations in the WLAN jeopardizes the provisioning of the service guarantees committed to the EDCA stations. The reason is that DCF stations compete with Contention Windows (CW ’s) that are predefined and cannot be modified, and as a result the impact of the DCF stations on the service re...

Directional distributed co-ordination function (D-DCF), a modified medium access control protocol of IEEE 802.11, is proposed to support hybrid antennas such as smart adaptive array antennas and normal omni-directional antennas, in one wireless local area network cell. Nodes equipped with smart antennas follow D-DCF and nodes equipped with normal antennas follow DCF. D-DCF based on a hybrid vir...

The aim of this study was to determine the role of small intestinal (SI) cytochrome P450 (P450) enzymes in the metabolic activation of diclofenac (DCF), a widely used nonsteroidal anti-inflammatory drug, and DCF-induced intestinal toxicity. DCF induces intestinal ulcers in humans and mice, but the underlying mechanisms, including the necessity for drug bioactivation in the target tissues and th...

2'-Deoxycoformycin (dCF) as a single agent has been reported to be less effective against myeloid than against lymphoid malignancies in clinical trials. However, previous studies have shown that in the presence of 2'-deoxyadenosine (dAd), human monocytoid leukemia cell lines are much more sensitive to dCF with regard to the inhibition of cell proliferation. Thus, dCF might be useful for treatin...