Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. The purpose of this study was to determine the effects of daucosterol on HCC by investigating Wnt/β-catenin signaling. In this study, HepG2 and SMMC-7721 cells were treated with varying concentrations of daucosterol, and the corresponding inhibitory effects on HCC cells were examined via CCK-8 assays....

A new acylated triterpene together with prunasin, (-)-epicatechin, daucosterol, and three triterpenes, ursolic, oleanolic, and pomolic acids was isolated from the root of Chaenomeles japonica (THUNB.) LINDL. (Rosaceae) and determined to be 3-O-(E)-3, 5-dihydroxycinnamoylursolic acid on the basis of NMR and FAB-MS experiments.

achillea tenuifolia lam (asteraceae) afforded a methanolic extract from which after fractionation in solvents with different polarities two known flavones 3’, 5- dihydroxy- 4’, 6, 7- trimethoxy flavone (eupatorine, compound 3), 5- hydroxy- 3’, 4’, 6, 7- tetramethoxyflavone (compound 4), besides stearic acid (compound 1 ), lupeol (compound 2), daucosterol (β- sitosterol 3-o- β- d- glucopyranosid...

Isolation and GC/MS quantitative determination of ursolic acid in the herb of Nepeta cataria var. citriodora have been performed. The content of this compound was in the range 0.95 ñ 1.30%. Daucosterol (βsitosterol 3-O-β-D-glucoside) was also isolated from the plant, in addition to small amounts of β-sitosterol, campesterol, α-amyrin and β-amyrin. The content and composition of essential oil in...

Aerva lanata (Linn.) Juss. ex Schult. (Family-Amaranthaceae) is an important source of chemicals of immense medicinal and pharmaceutical importance such as O-acyl glycosides, β-sitosterol, daucosterol, syringic acid, vanillic acid, feruloyl tyramine, feruloyl homovanillylamine, narcissin and aervitrine which are effective as diuretic, anthelmintic, antidiabetic, expectorant and in the treatment...

The aim of this study was to ascertain the anti-arthritic active fraction of Capparis spinosa L. (Capparidaceae) fruits and its chemical constituents. The adjuvant arthritic rat model was developed to evaluate the anti-arthritic effects of different fractions of ethanol extraction from C. spinosa L. The fraction eluted by ethanol-water (50:50, v/v) had the most significant anti-arthritic activi...

A new acyclic guanidine alkaloid, canarosine (1), together with five known compounds, beta-sitosterol (2), stigmasterol (3), daucosterol (4), epi-inositol 6-O-methyl ether (5), and rutin (6), were isolated from the aerial parts of Canavalia rosea. Their structures were established on the basis of their spectroscopic data. In the radioligand receptor binding assay, canarosine (1), at a concentra...

ent-Kaurene diterpenoids, phyllostachysins D-H (1-5), together with nine known compounds, rabdoloxins A-B (6-7), rabdoinflexin B (8), amethystoidin A (9), rabdokunmin D (10), macrocalyxin E (11), 5,7-dihydroxy-4'-hydroxylflavone (12), oleanolic acid (13) and daucosterol (14), were isolated from aerial parts of Isodon phyllostachys. Structures were elucidated on the basis of spectroscopic method...

Among the natural compounds, terpenoids play an important role in the drug discovery process for tropical diseases. The aim of the present work was to isolate antiprotozoal compounds from Ambrosia elatior and A. scabra. The sesquiterpene lactone (STL) cumanin was isolated from A. elatior whereas two other STLs, psilostachyin and cordilin, and one sterol glycoside, daucosterol, were isolated fro...