apoptosis plays an important role in many pathological processes of the central nervous system. the neuroprotective effect of periodic fasting (pf) in contrast to severe fasting or starvation has been suggested. however, these beneficial effects seem to depend on the type and duration of the used feeding protocol. this study was designed to evaluate the effects of different pf protocols on the ...

the n-methyl-d-aspartic acid (nmda) receptor is one of the specific types of ionotropic receptors which lied to glutaminergic system. it has been widely accepted that nmda receptor neurons promote anxiety, in humans as well as in animal models. however, in the previous study seems inhibiting of this receptors decreased the protective role in neural cell. demonstration of nmda receptor activity ...

objective(s):silver nanoparticles (ag-nps) are used widely in bedding, water purification, tooth paste and toys. these nanoparticles can enter into the body and move into the hippocampus. the aim of this study was to investigate the neurotoxicity of silver nanoparticles in the adult rat hippocampus. materials and methods:12 male wistar rats were randomly divided into two experimental and contro...

Objective(s):Silver nanoparticles (Ag-NPs) are used widely in bedding, water purification, tooth paste and toys. These nanoparticles can enter into the body and move into the hippocampus. The aim of this study was to investigate the neurotoxicity of silver nanoparticles in the adult rat hippocampus. Materials and Methods:12 male Wistar rats were randomly divided into two experimental and contro...

Background: Curcumin is the most active ingredient in turmeric root of Curcuma longa of the Zingiberaceae family and has a potent antioxidant activity. This study aimed at investigating the effects of curcumin with various doses on the density of dark neurons in the hippocampus of induced D-galactose aging mice model. This experimental study was conducted on 40 adult male BALB/c mice.  Materia...

BACKGROUND Diabetes mellitus type 1 is a chronic endogenous stressor. We investigated the effects of a diabetes mellitus type 1 on dark neuron formation in granular layer of dentate gyrus. MATERIALS AND METHODS Diabetes was induced by a single intraperitoneal (IP) injection of streptozotocin (STZ) at a dose of 60 mg/kg dissolved in saline. Control animals were received only saline. In the end...

This paper aims to analyze the circadian behavior of the population of suprachiasmatic nucleus(SCN) neuron by light-dark cycle. Self-sustained oscillation is generated in individual SCN neuron by a molecular regulatory network. Cells oscillate with different periods, but the SCN neurons display significant synchronization under the effect of the light-dark(LD) cycle. We present a model for a po...

Dark neurons are seen in neurosurgical biopsies, experimental ischemia, hypoglycemia, and epilepsy. This study was aimed to investigate probable damage of amygdala due to pentylenetetrazol (PTZ) induced acute seizures in rat. Male Wistar rats were divided into control, sham, and PTZ groups. EEG recordings were performed before and after the PTZ injection in PTZ group. Dark neuron numbers in amy...

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