In August 2015, Turing Pharmaceuticals acquired the marketing rights to Daraprim (pyrimethamine), a drug used to treat parasitic infections like malaria and toxoplasmosis. Soon after, Turing caused an uproar when it announced that it would raise the price per tablet of Daraprim from [Formula: see text], a 5500% price hike for a drug that has been on the market for over 60 years and off patent s...

in this study, a crude leishmanial antigen, was prepared by sonicating leishmania major promastigotes used to induce immunity in balb/c mice against cutaneous leishmaniasis. correlation between the route of antigen injection and the efficacy of induced protection was examined. to enhance the effectiveness of the antigen, an immunostimulant drug, daraprim (pyrimethamine), was administered simult...

seizures. In view of the risk and the serious consequences if tonic-clonic seizures are provoked, some people with epilepsy may prefer to plan their itinerary so that they avoid the need to take antimalarial drugs. 1 Torrey EF. Chloroquine seizures.JAMA 1968;204:867-70. 2 Kiel FW. Chloroquine suicide.JAMA 1964;190:398-400. 3 Grisham RSC. Central nervous system toxicity of pyrimethamine (Darapri...

ALTHOUGH toxoplasmosis was suggested as a cause of congenital choroidoretinitis over 30 years ago, the definite importance of the organism in the acquired disease is still in doubt. The early observations of Janku (1923) and Torres (1927) attracted little attention until Wolf and Cowen (1937) isolated the parasite from a fatal human case. The frequent occurrence of retinitis in the neonatal cas...

I. The Pharmacology of No. 48-80, a Long-Acting Vasodepressor Drug. Peter B. Dews, A. Lloyd Wnuck, R. V. Fanelli, Amos E. Light, John A. Tornaben, Stata Norton, C. H. Ellis and Edwin J. De Beer 1 II. Studies on the Relationship of Metabolic Fate and Hormonal Effects of d,l-Methadone to the Development of Drug Tolerance. Chen-Y#{252} Sung, E. Leong Way and Kenneth G. Scott 12 III. The Action of ...

The serum protein patterns of groups of Nigerians including 98 children partially protected by "daraprim" against malaria, and 113 unprotected children, have been studied. The protected children have a significantly lower concentration of serum gamma globulin than the unprotected children from the age of 12 months onwards. In children, sicklers have a significantly higher serum gamma globulin t...