نتایج جستجو برای: daminozide
تعداد نتایج: 69 فیلتر نتایج به سال:
The influence of daminozide, an inhibitor of gibberellins biosynthesis, on the somatic embryogenesis in immature and mature embryo derived from tissue cultures of wheat was investigated. Low concentrations of daminozide (0.064-0.127 mM) positively affected the somatic embryogenic capacity of immature embryos (cv. ‘Andros’) cultured on the medium supplemented with either 2,4-dichlorophenoxyaceti...
The JmjC oxygenases catalyze the N-demethylation of N(ε)-methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related oxygenases. Results led to the finding that daminozide (N-(dimethylamino)succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the...
Daminozide, a plant growth regulator, is an effective inhibitor of the Jumonji domain-containing protein (JMJD) histone demethylase. Herein, four ruthenium(II)/rhenium(I)-daminozide conjugates, with molecular formulas [Ru(N-N)2bpy(4-CH2OH-4′-CH2O-daminozide)](PF6)2 (Ru-1/Ru-2) (N-N = 1,10-phenanthroline (phen, in Ru-1) and 4,7-diphenyl-1,10-phenanthroline (DIP, Ru-2)) Re(N-N)(CO)3(PyCH2O-damino...
Pot marigold (Calendula officinalis L.) is a medicinal and ornamental plant. The effect of different concentrations of chlormequat (cycocel), and daminozide, two plant growth retardant, on plant height, flowering, the content of essence and some other traits in pot marigold (Calendula officinalis) was assessed. Plant growth retardants are commonly applied to limit stem elongation and produce a ...
pot marigold (calendula officinalis l.) is a medicinal and ornamental plant. the effect of different concentrations of chlormequat (cycocel), and daminozide, two plant growth retardant, on plant height, flowering, the content of essence and some other traits in pot marigold (calendula officinalis) was assessed. plant growth retardants are commonly applied to limit stem elongation and produce a ...
1 N-nitrosodimethylamine (NDMA) is an emerging disinfection by-product, and we show 2 that use of chlorine dioxide (ClO2) has the potential to increase NDMA formation in waters 3 containing precursors with hydrazine moieties. NDMA formation was measured after 4 oxidation of 13 amines by monochloramine, ClO2 and pre-treatment with ClO2 followed by 5 post-monochloramination. Daminozide, a plant g...
Alterations of histone methylation dynamically regulated by methyltransferases and demethylases are frequently found in human cancers. Here, we showed that expression of lysine demethylase 2A (KDM2A) is markedly increased in human breast cancer and its overexpression is associated with tumor progression and poor prognosis. Knockdown of KDM2A in breast cancer cells reduced proliferation but not ...
In the analysis by Parry et al. [Parry, J. M., Parry, E., Phrakonkham, P. and Corvi, R. (2010) Analysis of published data for top concentration considerations in mammalian cell genotoxicity testing. Mutagenesis, 25, 531-538], 24 rodent carcinogens that were negative in the Ames test were identified that were only positive in mammalian cell tests at concentrations between 1 and 10 mM. These carc...
[methyl-14C]Daminozide (succinic acid 2',2'-dimethylhydrazide; 37 mg/kg), 1,1-[14C]dimethylhydrazine (UDMH; 19 mg/kg), and [14C]dimethylnitrosamine (DMNA; 0.1 mg/kg) were administered by oral gavage to male Sprague-Dawley rats. After 24 hr, the animals were killed and DNA was purified from the livers to constant specific radioactivity. After enzymatic degradation of the DNA to the 3'-deoxynucle...
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