The authors comment on the article by Róna et al. [(2013), Acta Cryst. D69, 2495-2505].

The authors respond to a comment by Alvisi & Jans [(2014), Acta Cryst. D70, 2775-2776] on the article Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights [Róna et al. (2013), Acta Cryst. D69, 2495-2505].

In order to regulate gene expression, transcription factors must first bind their target DNA sequences. The affinity of this binding is determined by both the network of interactions at the interface and the entropy change associated with the complex formation. To study the role of structural fluctuation in fine-tuning DNA affinity, we performed molecular dynamics simulations of two highly homo...

We apply the probability distribution function method to the study of chiral properties of QCD with quarks in the exact massless limit. A relation among the chiral condensate, zeros of the Bessel function and eigenvalue of Dirac operator is also given. The chiral condensate in this limit can be measured with small number of eigenvalues of the massless Dirac operator and without any ambiguous ma...

How could well-being data, for example those based on survey measures, be used for guiding policy? Exploring one direction, we analyze a mechanism that takes as inputs estimates of policy effects on different groups’ utility proxies (constructed from the well-being data), and aggregates them into policy-change recommendations. We develop three justifications for the mechanism based on: an analo...