Tirbanibulin 1% ointment was approved for actinic keratosis (AK) of face or scalp based on two Phase 3 trials. Pooled rates complete (100%) clearance (CC) and partial (≥75%) (PC) in these trials were reported Day (D) 57 treatment, being 49% 72% respectively. We present post-hoc efficacy safety analyses evaluating earlier time points. Participants (N=702) the had 4-8 clinically visible AK lesion...

This note argues about a central analytical inconsistency of Ericson and Pakes (1995). Notwithstanding the explicit claims of the article, the formal hypotheses employed there imply that a firm’s investments do not affect both the evolution of this firm and the dynamics of the whole industry. JEL Classification Numbers: C62, D57, E13, L11.

This paper suggests a new methodology for evaluating technological change in a multi-sector general equilibrium framework. The double calibration technique was applied to an ex post decomposition analysis of technological change between two periods, enabling a distinction to be made between price-induced and factor-biased technological changes for each sector. The method is applied to an empiri...

In this paper we present new measures for the bias in an import price index due to outsourcing. The m easure is developed fi rst for a high ly simplif ied case for the purpose of conveying the rationale for the measure. It is then generalized, yielding a m eaasure that could b e used in empirical stu dies. Before taking up this bias measurement problem , however, we expl ain the m easurement co...

The aggregation level of industries in the Danish macroeconomic model ADAM is examined using a new indicator of aggregation bias. The indicator is decomposed into contributions from the original industries, thereby clearly identifying the aggregation problems which caused the 6 industry groups of the older versions of ADAM to be disaggregated into the current 19 groups. An aggregation key minim...

Abstract. We describe recent work due to Niall Ó Murchadha and the author (grqc/9706046, Phys. Rev. D57, 4728 (1998)) on the late time behaviour of the maximal foliation of the extended Schwarzschild geometry which results from evolving a time symmetric slice into the past and future, with time running equally fast at both spatial ends of the manifold. We study the lapse function of this foliat...

This paper addresses the question whether the results of input-output (IO) impact analyses differ (and to what extent) when a framework in current prices or in constant prices is used. We consider the effect of an exogenous stimulus of final demand in current prices on (a) gross output in constant prices, and (b) employment. In an empirical application to Denmark, we found that all predicted ef...

Shigellosis is a mild-to-severe diarrheal infection, caused by the genus Shigella, and is responsible for significant morbidity and mortality worldwide. We evaluated the safety and immunogenicity of an investigational Shigella sonnei vaccine (1790GAHB) based on generalized modules for membrane antigens (GMMA) in Kenya, a Shigella-endemic country. This phase 2a, observer-blind, controlled random...