نتایج جستجو برای: d1b

تعداد نتایج: 147  

Journal: :International journal of clinical and experimental pathology 2014
Ning Wang Heng Wei Duo Yin Yanming Lu Yao Zhang Di Jiang Yan Jiang Shulan Zhang

Cyclin D1b is one of two proteins translated from cyclin D1 transcripts (isoforms a and b) that are generated due to gene polymorphism. Our previous study has reported low cyclin D1b expression in cervical cancer tissue, with an expression level in moderately or poorly differentiated tissues that was significantly lower than that in well-differentiated tissues. However, the functional role of c...

Journal: :Oncology letters 2016
Chul Jang Kim Yukihiro Tambe Ken-Ichi Mukaisho Hiroyuki Sugihara Akihiro Kawauchi Hirokazu Inoue

A total of two major isoforms, cyclin D1a and cyclin D1b, are generated from the human cyclin D1 gene by alternative splicing. Cyclin D1b is scarcely expressed in normal tissues; however, it is expressed at a high frequency in certain types of cancerous tissue. The present authors previously constructed cyclin D1b transgenic (Tg) mice and identified rectal tumors, including adenocarcinoma and s...

2015
Michael A Augello Lisa D Berman-Booty Richard Carr Akihiro Yoshida Jeffry L Dean Matthew J Schiewer Felix Y Feng Scott A Tomlins Erhe Gao Walter J Koch Jeffrey L Benovic John Alan Diehl Karen E Knudsen

Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from cyclin D1 to cyclin D1b. Extensive analyses uncovered overlapping but non-redundant functions of cyclin D1b compared to cyclin D1 on developmental phenotyp...

Journal: :The Journal of biological chemistry 1994
M Tiberi M G Caron

Dopamine D1A and D1B receptor subtypes belong to the superfamily of G protein-coupled receptors. Both receptors are coupled to the activation of adenylyl cyclase and exhibit distinct brain distribution. To identify functional differences, binding and stimulation of adenylyl cyclase were assessed in 293 cells expressing transiently either dopamine D1A or D1B receptors. Membranes expressing D1B r...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Craig J Burd Christin E Petre Lisa M Morey Ying Wang Monica P Revelo Christopher A Haiman Shan Lu Cecilia M Fenoglio-Preiser Jiwen Li Erik S Knudsen Jiemin Wong Karen E Knudsen

Cyclin D1 is a multifaceted regulator of both transcription and cell-cycle progression that exists in two distinct isoforms, cyclin D1a and D1b. In the prostate, cyclin D1a acts through discrete mechanisms to negatively regulate androgen receptor (AR) activity and thus limit androgen-dependent proliferation. Accordingly, cyclin D1a is rarely overexpressed in prostatic adenocarcinoma and holds l...

2008
Ying Wang Jeffry L. Dean Ewan K.A. Millar Thai Hong Tran Catriona M. McNeil Craig J. Burd Susan M. Henshall Fransiscus E. Utama Agnieszka Witkiewicz Hallgeir Rui Robert L. Sutherland Karen E. Knudsen Erik S. Knudsen

Cyclin D1 is a key mediator of cell cycle progression that is aberrantly regulated in multiple cancers, especially in breast cancers. A number of studies have indicated that a polymorphism in a splice donor site in the cyclin D1 gene is associated with alternative splicing and the production of the alternative cyclin D1b transcript. Furthermore, this polymorphism is selectively associated with ...

Journal: :Cancer research 2008
Ying Wang Jeffry L Dean Ewan K A Millar Thai Hong Tran Catriona M McNeil Craig J Burd Susan M Henshall Fransiscus E Utama Agnieszka Witkiewicz Hallgeir Rui Robert L Sutherland Karen E Knudsen Erik S Knudsen

Cyclin D1 is a key mediator of cell cycle progression that is aberrantly regulated in multiple cancers, especially in breast cancers. A number of studies have indicated that a polymorphism in a splice donor site in the cyclin D1 gene is associated with alternative splicing and the production of the alternative cyclin D1b transcript. Furthermore, this polymorphism is selectively associated with ...

Journal: :Cancer research 2010
Maria Paola Paronetto Manuela Cappellari Roberta Busà Simona Pedrotti Roberta Vitali Clay Comstock Terry Hyslop Karen E Knudsen Claudio Sette

Human cyclin D1 is expressed as two isoforms derived by alternate RNA splicing, termed D1a and D1b, which differ for the inclusion of intron 4 in the D1b mRNA. Both isoforms are frequently upregulated in human cancers, but cyclin D1b displays relatively higher oncogenic potential. The splicing factors that regulate alternative splicing of cyclin D1b remain unknown despite the likelihood that th...

Journal: :Anticancer research 2010
Vandana Gupta Abramson Andrea B Troxel Michael Feldman Carolyn Mies Yan Wang Lauren Sherman Sara McNally Alan Diehl Angela Demichele

BACKGROUND/AIM Cyclin D1 is a mediator of cell-cycle control that is frequently overexpressed in primary ductal breast carcinomas, but its role is controversial. A polymorphism in the CCND1 gene, G870A, results in an aberrantly spliced protein (cyclin D1b) lacking the Thr-286 phosphorylation site necessary for nuclear export. Studies of murine fibroblasts have shown that although overexpression...

Journal: :Cancer research 2010
Nicholas A Olshavsky Clay E S Comstock Matthew J Schiewer Michael A Augello Terry Hyslop Claudio Sette Jinsong Zhang Linda M Parysek Karen E Knudsen

The cyclin D1b oncogene arises from alternative splicing of the CCND1 transcript, and harbors markedly enhanced oncogenic functions not shared by full-length cyclin D1 (cyclin D1a). Recent studies showed that cyclin D1b is selectively induced in a subset of tissues as a function of tumorigenesis; however, the underlying mechanism(s) that control tumor-specific cyclin D1b induction remain unsolv...

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