نتایج جستجو برای: cytoprotective
تعداد نتایج: 4389 فیلتر نتایج به سال:
in the present study, free-radical-scavenging and antioxidant activities of angipars™, an herbal extract which has been registered as a therapeutic drug for diabetic foot ulcer, were examined. we investigated the protective effect of angipars™ on cytotoxicity produced by exposure to h2o2 (300 µm) in hepg2 and a549 cell lines, using mtt assay, glutathione (gsh) content analysis, and lipid peroxi...
The bromodomain and extra-terminal domain (BET) family inhibitors are small molecules that target the dysregulated epigenetic readers, BRD2, BRD3, BRD4 BRDT, at various transcription-related sites, including super-enhancers. BET currently under investigation both in pre-clinical cell culture tumor-bearing animal models, as well clinical trials. However, is case with other chemotherapeutic modal...
Medicinal plants have been widely studied to identify plant-based anti-gastric ulcer medicines. The mechanism of gastroprotective action is important discover the potential lead compounds for drug development. All relevant articles between 2011 and 2021 focusing on Malaysian were collected analyzed understand underlying pathways. Keywords include peptic ulcer, gastric NSAIDs (Non-Steroidal Anti...
Vascular endothelial injury predisposes to endothelial dysfunction and atherogenesis. We have investigated the hypothesis that PKCε (protein kinase Cε) is an important upstream regulator of cytoprotective pathways in vascular ECs (endothelial cells). Depletion of PKCε in human ECs reduced expression of the cytoprotective genes A1, A20 and Bcl-2. Conversely, constitutively active PKCε expressed ...
Many genetic and physiological treatments that extend lifespan also confer resistance to a variety of stressors, suggesting that cytoprotective mechanisms underpin the regulation of longevity. It has not been established, however, whether the induction of cytoprotective pathways is essential for lifespan extension or merely correlated. Using a panel of GFP-fused stress response genes, we identi...
Gastric Antiseeretory and Cytoprotective Activities of SCH 28080. Studies on the Mechanisms of the Antisecretory and Cytoprotective Actions of SCH 28080.
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