The results of a limited number of studies on echinoderms provide evidence for the presence of a cytochrome P450 monooxygenase system in representatives of three classes of the phylum Echinodermata: the asteroids (sea stars), holothuroids (sea cucumbers) and echinoids (sea urchins). The monooxygenase system has been demonstrated to be involved in the metabolism of xenobiotic compounds, but is a...

beauveria spp. as entomopathogenic fungi have extremely diverse insect host ranges.here, a comparative transcript analysis of a bassiasin i (bsni), a dipeptidyl peptidase (dpp), a cytochrom p450 monooxygenase (cyp52), a mitogen activated protein kinase (mapk), and a neuronal calcium sensor 1 (ncs) in two isolates of beauveria bassiana., with low and high virulence, were carried out. for this, i...

Squalene monooxygenase is a microsomal enzyme that catalyzes the conversion of squalene to 2,3(s)-oxidosqualene, the immediate precursor to lanosterol in the cholesterol biosynthesis pathway. Unlike other flavoprotein monooxygenases that obtain electrons directly from NAD(P)H, squalene monooxygenase requires a redox partner, and for many years it has been assumed that NADPH-cytochrome P450 redu...

The cytochrome P450 monooxygenases are an important metabolic system whose level of activity can be influenced by several dietary constituents. We examined the effects of six known P450 inducers on the levels of total cytochromes P450, cytochrome b(5), and six monooxygenase activities in adult German cockroaches. In addition, the levels of CYP6L1 and CYP9E2 mRNA were also investigated. Phenobar...

This article discusses issues related to the role of biotransformation or metabolism antipsychotics (APs) in liver. There are three phases APs metabolism. Cytochrome P450 monooxygenase, an oxidase with mixed functions, plays a key most APs, participating first phase The functional activity cytochrome enzymes depends on carriage single nucleotide variants (SNVs) genes encoding these enzymes, as ...

Specific metabolic roles of P450-dependent monooxygenase systems are determined by enzymatic properties and substrate specificity of P450s, the terminal enzymes of the electron transfer chain. On the other hand, molecular diversity has also been reported for NADPH-cytochrome P450 reductase, cytochrome b5, and cytochrome b5 reductase in plants. Several lines of evidence indicate that the electro...

Correction In our article (Sirim et al. BMC Struct Biol 2010, 10: 34) [1] the cytochrome P450 monooxygenase P450cam was referred to as CYP101D. In the latest release 3.0 of our cytochrome P450 database CYPED (www.CYPED.uni-stuttgart.de) P450cam was reassigned to family CYP101A and referred to as CYP101A1.

Cyclohexanone monooxygenase (CHMO) was used as a model enzyme to find suitable freeze-drying conditions for long-term storage of an isolated monooxygenase. CHMO is a Baeyer-Villiger monooxygenase (BVMO) known for its ability to catalyze a large number of oxidation reactions. With a focus on establishing the optimal formulation, additives were tested for enzyme stabilization during and after lyo...