conclusions race, age, body surface area, chronic kidney disease, cyp2c9*3 level, and vkorc1 variants could affect the dose of warfarin. to administer the proper doses of warfarin, patients and physicians might achieve the best results with the pharmacologist proficient anticoagulation database and recommended continuation program. owing to its’ unpredictability, caution must be taken when pres...

conclusions the results of this study demonstrated that the p450 cyp141 gene was successfully cloned into a pet26b plasmid vector as an expression vector. in this paper, for the first time in iran, this gene was cloned for more purposes, including the expression and purification of the recombinant cytochrome p450 cyp141 protein. results the cloning of p450 cyp141 gene was confirmed by the enzym...

persian gazelle, gazella subgutturosa, exists throughout arid and semiarid regions of iran and has a key role in these frail ecosystems. habitat degradation and population decline has placed it on the list of vulnerable species in 2008. the phylogenetic relationships of three persian gazelle populations in the central part of iran (i.e. ghamishlou national park and wildlife refuge, mouteh wildl...

veritable identification and differentiation of avian species is a vital step in conservative, taxonomic, forensic, legal and other ornithological interventions. therefore, this study involved the application of molecular approach to identify some avian species i.e. chicken (gallus gallus), muskovy duck (cairina moschata), japanese quail (coturnix japonica), laughing dove (streptopelia senegale...

it has been known that cardiomyocytes possess a remarkable ability to downregulate their energy expenditure on restricted 02 supply. however it has also been speculated that an ability to suppress aerobic respiration and atp utilization could be a protective response to prolonged hypoxia. having the role of the cytochrome oxidase enzyme in mind, one can ask if its inhibition by using cyanide ha...

Introduction: Oxygenated water intake can increase cell death markers by increasing free radicals; however, sport activities and antioxidant substances can prevent some symptoms of free radical production. The purpose of this study was to investigate the effect of endurance training (ET) and purslane (portulaca oleracea) seed (PO) consumption on cytochrome-C and malondialdehyde...

a “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome p450 enzymes in one session. some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. our presented work was to aim on the influence of bupropion on rat cytochrome p450-mediated metabolism of tolbutamide. the biotransformation rates of tolbutam...

alcanivorax borkumensis is a marine bacterium that has ability to grow on limited substrates that mainly is alkanes. the ability to use wide range of hydrocarbons is advantage of this bacterium to other marine community bacteria. a. borkumensis have two genetic systems for alkane biodegradation. the first system is alkane hydroxylase (alk-b1and alk-b2) and the second system is  cytochrome p450....